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IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis.
J Urol. 2000 Jul; 164(1):214-8.JU

Abstract

PURPOSE

Chronic Prostatitis, or Chronic Pelvic Pain Syndrome [CPPS], is a common disorder characterized by pelvic pain and varying degrees of inflammation in expressed prostatic secretions (EPS). In search of markers to more clearly define CPPS, we compared proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels in EPS from men with CPPS, to healthy men and men with Benign Prostatic Hyperplasia (BPH).

METHODS

78 men: controls (n = 16), BPH (n = 14), CPPS IIIA [>/=10 white blood cells per high power field (WBC/hpf) in EPS] (n = 18), CPPS IIIB [<10 WBC/hpf in EPS] (n = 20), and asymptomatic inflammatory prostatitis (AIP) (n = 10) were evaluated for EPS WBC, and IL-1beta and TNF-alpha by ELISA.

RESULTS

IL-1beta and TNF-alpha levels in EPS were usually detectable in men with CPPS IIIA (89% and 45%, respectively) or AIP (90%; 100%), but less often in controls (31%; 17%), BPH (57%; 15%), and CPPS IIIB (35%; 15%) respectively. IL-1beta and TNF-alpha levels were higher in CPPS IIIA versus CPPS IIIB, and in AIP versus controls or BPH (p's <0.001). Cut-points for IL-1beta and TNF-alpha discriminated AIP from controls (predictive values = 94% and 83%, respectively) and CPPS IIIA from CPPS IIIB (predictive values 84% and 100%). Overall, there was a correlation between IL-1beta and TNF-alpha (p <0.003), but no correlation between WBC and IL-1beta (p <0.1) or TNF-alpha (p <0.50).

CONCLUSIONS

Cytokines are frequently present and elevated in the EPS from men with CPPS IIIA and AIP and provide a novel means for identification, characterization and potential management of men with CPPS that differs from traditional methods based on WBC.

Authors+Show Affiliations

Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10840462

Citation

Nadler, R B., et al. "IL-1beta and TNF-alpha in Prostatic Secretions Are Indicators in the Evaluation of Men With Chronic Prostatitis." The Journal of Urology, vol. 164, no. 1, 2000, pp. 214-8.
Nadler RB, Koch AE, Calhoun EA, et al. IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. J Urol. 2000;164(1):214-8.
Nadler, R. B., Koch, A. E., Calhoun, E. A., Campbell, P. L., Pruden, D. L., Bennett, C. L., Yarnold, P. R., & Schaeffer, A. J. (2000). IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. The Journal of Urology, 164(1), 214-8.
Nadler RB, et al. IL-1beta and TNF-alpha in Prostatic Secretions Are Indicators in the Evaluation of Men With Chronic Prostatitis. J Urol. 2000;164(1):214-8. PubMed PMID: 10840462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. AU - Nadler,R B, AU - Koch,A E, AU - Calhoun,E A, AU - Campbell,P L, AU - Pruden,D L, AU - Bennett,C L, AU - Yarnold,P R, AU - Schaeffer,A J, PY - 2000/6/7/pubmed PY - 2000/7/15/medline PY - 2000/6/7/entrez SP - 214 EP - 8 JF - The Journal of urology JO - J. Urol. VL - 164 IS - 1 N2 - PURPOSE: Chronic Prostatitis, or Chronic Pelvic Pain Syndrome [CPPS], is a common disorder characterized by pelvic pain and varying degrees of inflammation in expressed prostatic secretions (EPS). In search of markers to more clearly define CPPS, we compared proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels in EPS from men with CPPS, to healthy men and men with Benign Prostatic Hyperplasia (BPH). METHODS: 78 men: controls (n = 16), BPH (n = 14), CPPS IIIA [>/=10 white blood cells per high power field (WBC/hpf) in EPS] (n = 18), CPPS IIIB [<10 WBC/hpf in EPS] (n = 20), and asymptomatic inflammatory prostatitis (AIP) (n = 10) were evaluated for EPS WBC, and IL-1beta and TNF-alpha by ELISA. RESULTS: IL-1beta and TNF-alpha levels in EPS were usually detectable in men with CPPS IIIA (89% and 45%, respectively) or AIP (90%; 100%), but less often in controls (31%; 17%), BPH (57%; 15%), and CPPS IIIB (35%; 15%) respectively. IL-1beta and TNF-alpha levels were higher in CPPS IIIA versus CPPS IIIB, and in AIP versus controls or BPH (p's <0.001). Cut-points for IL-1beta and TNF-alpha discriminated AIP from controls (predictive values = 94% and 83%, respectively) and CPPS IIIA from CPPS IIIB (predictive values 84% and 100%). Overall, there was a correlation between IL-1beta and TNF-alpha (p <0.003), but no correlation between WBC and IL-1beta (p <0.1) or TNF-alpha (p <0.50). CONCLUSIONS: Cytokines are frequently present and elevated in the EPS from men with CPPS IIIA and AIP and provide a novel means for identification, characterization and potential management of men with CPPS that differs from traditional methods based on WBC. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/10840462/IL_1beta_and_TNF_alpha_in_prostatic_secretions_are_indicators_in_the_evaluation_of_men_with_chronic_prostatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(05)67497-6 DB - PRIME DP - Unbound Medicine ER -