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Severe amyloidosis with mild multiple myeloma--an unusual course.
Haematologia (Budap). 2000; 30(1):55-9.H

Abstract

Amyloidosis may be primary or myeloma-associated. Skeletal lesions and the percentage of bone marrow plasma cells (<10% in primary, >20% in myeloma) account for the major differences between the two varieties. In the literature there are rare cases of primary amyloidosis presenting without myeloma and followed by development of myelomatous manifestations. Usually, the primary disease (i.e. the myeloma) is advanced, when amyloidosis is diagnosed. We describe a patient who had presented with a severe and progressive systemic amyloidosis and was diagnosed later to have a mild light chain myeloma. Aggressive treatment with melphalan, prednisone and colchicine resulted in a temporary partial remission, followed by a rapid downhill course, and the patient's death. The point of relatively mild myeloma following a rapidly progressive course of advanced amyloidosis is emphasized. Awareness of the possibility of such a combination may lead to early diagnosis, a more aggressive or novel therapeutic approach and, possibly, to a better prognosis.

Authors+Show Affiliations

Department of Medicine B, Rabin Medical Center, Petah Tikva, Sackler School of Medicine, Tel-Aviv University, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10841327

Citation

Zeidman, A, et al. "Severe Amyloidosis With Mild Multiple Myeloma--an Unusual Course." Haematologia, vol. 30, no. 1, 2000, pp. 55-9.
Zeidman A, Sender BZ, Yarmolovsky A, et al. Severe amyloidosis with mild multiple myeloma--an unusual course. Haematologia (Budap). 2000;30(1):55-9.
Zeidman, A., Sender, B. Z., Yarmolovsky, A., Fradin, Z., & Mittelman, M. (2000). Severe amyloidosis with mild multiple myeloma--an unusual course. Haematologia, 30(1), 55-9.
Zeidman A, et al. Severe Amyloidosis With Mild Multiple Myeloma--an Unusual Course. Haematologia (Budap). 2000;30(1):55-9. PubMed PMID: 10841327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe amyloidosis with mild multiple myeloma--an unusual course. AU - Zeidman,A, AU - Sender,B Z, AU - Yarmolovsky,A, AU - Fradin,Z, AU - Mittelman,M, PY - 2000/6/7/pubmed PY - 2001/2/28/medline PY - 2000/6/7/entrez SP - 55 EP - 9 JF - Haematologia JO - Haematologia (Budap) VL - 30 IS - 1 N2 - Amyloidosis may be primary or myeloma-associated. Skeletal lesions and the percentage of bone marrow plasma cells (<10% in primary, >20% in myeloma) account for the major differences between the two varieties. In the literature there are rare cases of primary amyloidosis presenting without myeloma and followed by development of myelomatous manifestations. Usually, the primary disease (i.e. the myeloma) is advanced, when amyloidosis is diagnosed. We describe a patient who had presented with a severe and progressive systemic amyloidosis and was diagnosed later to have a mild light chain myeloma. Aggressive treatment with melphalan, prednisone and colchicine resulted in a temporary partial remission, followed by a rapid downhill course, and the patient's death. The point of relatively mild myeloma following a rapidly progressive course of advanced amyloidosis is emphasized. Awareness of the possibility of such a combination may lead to early diagnosis, a more aggressive or novel therapeutic approach and, possibly, to a better prognosis. SN - 0017-6559 UR - https://www.unboundmedicine.com/medline/citation/10841327/Severe_amyloidosis_with_mild_multiple_myeloma__an_unusual_course_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=0017-6559&amp;volume=30&amp;issue=1&amp;spage=55&amp;aulast=Zeidman DB - PRIME DP - Unbound Medicine ER -