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Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat.
Can J Physiol Pharmacol. 2000 May; 78(5):423-7.CJ

Abstract

Recent studies have shown that nitric oxide (NO) biosynthesis increases in pregnancy and that inhibition of nitric oxide synthase (NOS) induces some pathological processes characteristic of preeclampsia. The current project sought to study the effect of the NOS inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME, 10 microg x min(-1), sc for 7 days) on plasma volume, plasma atrial natriuretic factor (ANF), plasma endothelin-1 (ET), and plasma renin activity (PRA) during gestation in conscious rats. NOS inhibition caused mean arterial pressure to increase in both virgin and 21-day pregnant rats. Plasma volume fell in the pregnant rats [L-NAME, 4.5 +/- 0.3 mL x 100 g(-1) body wt. (n = 7) vs. D-NAME, 6.8 +/- 0.2 mL x 100 g(-1) body wt. (n = 10); P < 0.05] but not in the virgin rats [L-NAME, 4.3 +/- 0.1 mL x 100 g(-1) body wt. (n = 6) vs. D-NAME, 4.8 +/- 0.2 mL x 100 g(-1) body wt. (n = 8)]. There was no effect of NOS inhibition on plasma ANF levels or PRA in either the virgin or pregnant rats. However, L-NAME did decrease plasma ET levels in the pregnant rats [L-NAME, 19.6 +/- 1.6 pg x mL(-1) (n = 8) vs. D-NAME, 11.6 +/- 2.5 pg x mL(-1) (n = 9); P < 0.05]. Our results confirm that NO is involved in cardiovascular homeostasis in pregnancy; NOS inhibition selectively reduces plasma volume in pregnant rats, thus mimicking a major pathophysiological perturbation of preeclampsia. However, it does not induce the hormonal changes characteristic of preeclampsia, namely the decrease in PRA and increase in plasma ET and ANF levels.

Authors+Show Affiliations

Department of Physiology, University of Alberta, Edmonton, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10841438

Citation

Zhang, Y, and S Kaufman. "Effect of Nitric Oxide Synthase Inhibition On Cardiovascular and Hormonal Regulation During Pregnancy in the Rat." Canadian Journal of Physiology and Pharmacology, vol. 78, no. 5, 2000, pp. 423-7.
Zhang Y, Kaufman S. Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat. Can J Physiol Pharmacol. 2000;78(5):423-7.
Zhang, Y., & Kaufman, S. (2000). Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat. Canadian Journal of Physiology and Pharmacology, 78(5), 423-7.
Zhang Y, Kaufman S. Effect of Nitric Oxide Synthase Inhibition On Cardiovascular and Hormonal Regulation During Pregnancy in the Rat. Can J Physiol Pharmacol. 2000;78(5):423-7. PubMed PMID: 10841438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat. AU - Zhang,Y, AU - Kaufman,S, PY - 2000/6/7/pubmed PY - 2000/9/23/medline PY - 2000/6/7/entrez SP - 423 EP - 7 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 78 IS - 5 N2 - Recent studies have shown that nitric oxide (NO) biosynthesis increases in pregnancy and that inhibition of nitric oxide synthase (NOS) induces some pathological processes characteristic of preeclampsia. The current project sought to study the effect of the NOS inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME, 10 microg x min(-1), sc for 7 days) on plasma volume, plasma atrial natriuretic factor (ANF), plasma endothelin-1 (ET), and plasma renin activity (PRA) during gestation in conscious rats. NOS inhibition caused mean arterial pressure to increase in both virgin and 21-day pregnant rats. Plasma volume fell in the pregnant rats [L-NAME, 4.5 +/- 0.3 mL x 100 g(-1) body wt. (n = 7) vs. D-NAME, 6.8 +/- 0.2 mL x 100 g(-1) body wt. (n = 10); P < 0.05] but not in the virgin rats [L-NAME, 4.3 +/- 0.1 mL x 100 g(-1) body wt. (n = 6) vs. D-NAME, 4.8 +/- 0.2 mL x 100 g(-1) body wt. (n = 8)]. There was no effect of NOS inhibition on plasma ANF levels or PRA in either the virgin or pregnant rats. However, L-NAME did decrease plasma ET levels in the pregnant rats [L-NAME, 19.6 +/- 1.6 pg x mL(-1) (n = 8) vs. D-NAME, 11.6 +/- 2.5 pg x mL(-1) (n = 9); P < 0.05]. Our results confirm that NO is involved in cardiovascular homeostasis in pregnancy; NOS inhibition selectively reduces plasma volume in pregnant rats, thus mimicking a major pathophysiological perturbation of preeclampsia. However, it does not induce the hormonal changes characteristic of preeclampsia, namely the decrease in PRA and increase in plasma ET and ANF levels. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/10841438/Effect_of_nitric_oxide_synthase_inhibition_on_cardiovascular_and_hormonal_regulation_during_pregnancy_in_the_rat_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10841438.ui DB - PRIME DP - Unbound Medicine ER -