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Ranking of optic disc variables for detection of glaucomatous optic nerve damage.
Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1764-73.IO

Abstract

PURPOSE

To describe optic disc variables assessed by evaluation of clinical optic disc photographs and to compare sensitivity and specificity of these optic disc parameters in identifying patients with ocular hypertension who have nerve fiber layer defects and normal visual fields and patients with visual field defects.

METHODS

The study included 500 normal subjects, 132 patients with ocular hypertension with retinal nerve fiber layer defects and normal visual fields (preperimetric glaucoma), and 840 patients with glaucomatous visual field defects. Color stereo optic disc photographs were morphometrically evaluated.

RESULTS

Highest diagnostic power for the separation between the normal group and the preperimetric glaucoma group had the vertical cup-to-disc diameter ratio corrected for its dependence on the optic disc size, total neuroretinal rim area, rim-to-disc area ratio corrected for disc size, and cup-to-disc area ratio corrected for disc size. Diagnostic power was lower for rim area in the temporal inferior and temporal superior disc sector, cup area corrected for disc size, and horizontal cup-to-disc diameter ratio corrected for disc size. Less useful for the differentiation between the normal subjects and the preperimetric glaucoma group were size of zones alpha and beta of parapapillary chorioretinal atrophy, and ratios of neuroretinal rim width and rim area comparing various optic disc sectors with each other.

CONCLUSIONS

In subjects with ocular hypertension with retinal nerve fiber layer defects and normal conventional achromatic visual fields, the vertical cup-to-disc diameter ratio corrected for optic disc size, total neuroretinal rim area, rim-to-disc area ratio, and cup-to-disc area ratio corrected for disc size are the most valuable optic disc variables for early detection of glaucomatous optic nerve damage. Correction for optic disc size is necessary for optic disc variables directly or indirectly derived from the optic cup. Parapapillary atrophy is less important in the early detection of glaucoma.

Authors+Show Affiliations

Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Germany. jost.jonas@augen.med.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10845597

Citation

Jonas, J B., et al. "Ranking of Optic Disc Variables for Detection of Glaucomatous Optic Nerve Damage." Investigative Ophthalmology & Visual Science, vol. 41, no. 7, 2000, pp. 1764-73.
Jonas JB, Bergua A, Schmitz-Valckenberg P, et al. Ranking of optic disc variables for detection of glaucomatous optic nerve damage. Invest Ophthalmol Vis Sci. 2000;41(7):1764-73.
Jonas, J. B., Bergua, A., Schmitz-Valckenberg, P., Papastathopoulos, K. I., & Budde, W. M. (2000). Ranking of optic disc variables for detection of glaucomatous optic nerve damage. Investigative Ophthalmology & Visual Science, 41(7), 1764-73.
Jonas JB, et al. Ranking of Optic Disc Variables for Detection of Glaucomatous Optic Nerve Damage. Invest Ophthalmol Vis Sci. 2000;41(7):1764-73. PubMed PMID: 10845597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ranking of optic disc variables for detection of glaucomatous optic nerve damage. AU - Jonas,J B, AU - Bergua,A, AU - Schmitz-Valckenberg,P, AU - Papastathopoulos,K I, AU - Budde,W M, PY - 2000/6/14/pubmed PY - 2000/6/17/medline PY - 2000/6/14/entrez SP - 1764 EP - 73 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 41 IS - 7 N2 - PURPOSE: To describe optic disc variables assessed by evaluation of clinical optic disc photographs and to compare sensitivity and specificity of these optic disc parameters in identifying patients with ocular hypertension who have nerve fiber layer defects and normal visual fields and patients with visual field defects. METHODS: The study included 500 normal subjects, 132 patients with ocular hypertension with retinal nerve fiber layer defects and normal visual fields (preperimetric glaucoma), and 840 patients with glaucomatous visual field defects. Color stereo optic disc photographs were morphometrically evaluated. RESULTS: Highest diagnostic power for the separation between the normal group and the preperimetric glaucoma group had the vertical cup-to-disc diameter ratio corrected for its dependence on the optic disc size, total neuroretinal rim area, rim-to-disc area ratio corrected for disc size, and cup-to-disc area ratio corrected for disc size. Diagnostic power was lower for rim area in the temporal inferior and temporal superior disc sector, cup area corrected for disc size, and horizontal cup-to-disc diameter ratio corrected for disc size. Less useful for the differentiation between the normal subjects and the preperimetric glaucoma group were size of zones alpha and beta of parapapillary chorioretinal atrophy, and ratios of neuroretinal rim width and rim area comparing various optic disc sectors with each other. CONCLUSIONS: In subjects with ocular hypertension with retinal nerve fiber layer defects and normal conventional achromatic visual fields, the vertical cup-to-disc diameter ratio corrected for optic disc size, total neuroretinal rim area, rim-to-disc area ratio, and cup-to-disc area ratio corrected for disc size are the most valuable optic disc variables for early detection of glaucomatous optic nerve damage. Correction for optic disc size is necessary for optic disc variables directly or indirectly derived from the optic cup. Parapapillary atrophy is less important in the early detection of glaucoma. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/10845597/Ranking_of_optic_disc_variables_for_detection_of_glaucomatous_optic_nerve_damage_ L2 - https://iovs.arvojournals.org/article.aspx?volume=41&issue=7&page=1764 DB - PRIME DP - Unbound Medicine ER -