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Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea.
J Gastroenterol Hepatol 2000; 15(5):512-8JG

Abstract

BACKGROUND

Decreased bone mineral density (BMD) is common in Western patients with inflammatory bowel disease (IBD). However, BMD has never been studied in Asia where the demographic and socio-economic status are different from the West. The aim of this study was to investigate the prevalence and mechanisms of osteopenia in newly diagnosed Korean patients with IBD.

METHODS

We studied 14 patients with Crohn's disease (CD) and 25 patients with ulcerative colitis (UC), all of whom had never been treated with corticosteroids. Bone mineral density was measured in the lumbar spine and the femoral neck by dual energy X-ray absorptiometry. Biochemical parameters including serum osteocalcin, parathyroid hormone, plasma inactive and active vitamin D, and urinary deoxypyridinoline were measured.

RESULTS

The BMD Z score at the lumbar spine was lower both in CD and in UC patients, but there was no significant difference between the two groups. There was no significant difference in nutritional status or biochemical parameters of bone metabolism between patients with a normal BMD and those with a decreased BMD.

CONCLUSIONS

Low BMD at the lumbar spine is common in newly diagnosed Korean patients with IBD, a result which is similar to Western studies. The mechanism for low bone mass remains undetermined; however, nutritional status and hormonal parameters of bone metabolism, and ethnic differences are not likely to be an important factor in the pathogenesis of this bone loss.

Authors+Show Affiliations

Department of Internal Medicine, Kyung Hee University College of Medicine, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10847438

Citation

Lee, S H., et al. "Decreased Trabecular Bone Mineral Density in Newly Diagnosed Inflammatory Bowel Disease Patients in Korea." Journal of Gastroenterology and Hepatology, vol. 15, no. 5, 2000, pp. 512-8.
Lee SH, Kim HJ, Yang SK, et al. Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea. J Gastroenterol Hepatol. 2000;15(5):512-8.
Lee, S. H., Kim, H. J., Yang, S. K., Kim, W. H., Joo, Y. S., Dong, S. H., ... Chang, R. (2000). Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea. Journal of Gastroenterology and Hepatology, 15(5), pp. 512-8.
Lee SH, et al. Decreased Trabecular Bone Mineral Density in Newly Diagnosed Inflammatory Bowel Disease Patients in Korea. J Gastroenterol Hepatol. 2000;15(5):512-8. PubMed PMID: 10847438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea. AU - Lee,S H, AU - Kim,H J, AU - Yang,S K, AU - Kim,W H, AU - Joo,Y S, AU - Dong,S H, AU - Kim,B H, AU - Lee,J I, AU - Chang,Y W, AU - Chang,R, PY - 2000/6/10/pubmed PY - 2000/10/14/medline PY - 2000/6/10/entrez SP - 512 EP - 8 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 15 IS - 5 N2 - BACKGROUND: Decreased bone mineral density (BMD) is common in Western patients with inflammatory bowel disease (IBD). However, BMD has never been studied in Asia where the demographic and socio-economic status are different from the West. The aim of this study was to investigate the prevalence and mechanisms of osteopenia in newly diagnosed Korean patients with IBD. METHODS: We studied 14 patients with Crohn's disease (CD) and 25 patients with ulcerative colitis (UC), all of whom had never been treated with corticosteroids. Bone mineral density was measured in the lumbar spine and the femoral neck by dual energy X-ray absorptiometry. Biochemical parameters including serum osteocalcin, parathyroid hormone, plasma inactive and active vitamin D, and urinary deoxypyridinoline were measured. RESULTS: The BMD Z score at the lumbar spine was lower both in CD and in UC patients, but there was no significant difference between the two groups. There was no significant difference in nutritional status or biochemical parameters of bone metabolism between patients with a normal BMD and those with a decreased BMD. CONCLUSIONS: Low BMD at the lumbar spine is common in newly diagnosed Korean patients with IBD, a result which is similar to Western studies. The mechanism for low bone mass remains undetermined; however, nutritional status and hormonal parameters of bone metabolism, and ethnic differences are not likely to be an important factor in the pathogenesis of this bone loss. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/10847438/Decreased_trabecular_bone_mineral_density_in_newly_diagnosed_inflammatory_bowel_disease_patients_in_Korea_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2000&volume=15&issue=5&spage=512 DB - PRIME DP - Unbound Medicine ER -