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Does lower esophageal sphincter incompetency contribute to esophageal bleeding?
Gastroenterology. 1976 Aug; 71(2):185-9.G

Abstract

The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control population (17.3 +/- 2.0 mm Hg). No differences were found among patients with ascites, variceal hemorrhage, or with different degrees of hepatic decompensation. In both patients and control subjects the LES responded with a significant pressure increase to gastric alkalinization. Symptoms and radiological evidence of gastroesophageal reflux were extremely uncommon in patients with liver cirrhosis. Based on these data it is unlikely that acid-pepsin regurgitation is a significant factor in the development of variceal hemorrhage.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1084840

Citation

Eckardt, V F., et al. "Does Lower Esophageal Sphincter Incompetency Contribute to Esophageal Bleeding?" Gastroenterology, vol. 71, no. 2, 1976, pp. 185-9.
Eckardt VF, Grace ND, Kantrowitz PA. Does lower esophageal sphincter incompetency contribute to esophageal bleeding? Gastroenterology. 1976;71(2):185-9.
Eckardt, V. F., Grace, N. D., & Kantrowitz, P. A. (1976). Does lower esophageal sphincter incompetency contribute to esophageal bleeding? Gastroenterology, 71(2), 185-9.
Eckardt VF, Grace ND, Kantrowitz PA. Does Lower Esophageal Sphincter Incompetency Contribute to Esophageal Bleeding. Gastroenterology. 1976;71(2):185-9. PubMed PMID: 1084840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does lower esophageal sphincter incompetency contribute to esophageal bleeding? AU - Eckardt,V F, AU - Grace,N D, AU - Kantrowitz,P A, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 185 EP - 9 JF - Gastroenterology JO - Gastroenterology VL - 71 IS - 2 N2 - The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control population (17.3 +/- 2.0 mm Hg). No differences were found among patients with ascites, variceal hemorrhage, or with different degrees of hepatic decompensation. In both patients and control subjects the LES responded with a significant pressure increase to gastric alkalinization. Symptoms and radiological evidence of gastroesophageal reflux were extremely uncommon in patients with liver cirrhosis. Based on these data it is unlikely that acid-pepsin regurgitation is a significant factor in the development of variceal hemorrhage. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1084840/Does_lower_esophageal_sphincter_incompetency_contribute_to_esophageal_bleeding L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508576001893 DB - PRIME DP - Unbound Medicine ER -