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A new highly effective short-term therapy schedule for Helicobacter pylori eradication.
Aliment Pharmacol Ther 2000; 14(6):715-8AP

Abstract

BACKGROUND

Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%).

AIM

To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication.

METHODS

A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or 13C urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended.

RESULTS

All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects.

CONCLUSIONS

The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation.

Authors+Show Affiliations

Department of Clinical Medicine, Gastroenteology II, 'La Sapienza' University, Rome, Italy. s.morini@flashnet.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10848654

Citation

Zullo, A, et al. "A New Highly Effective Short-term Therapy Schedule for Helicobacter Pylori Eradication." Alimentary Pharmacology & Therapeutics, vol. 14, no. 6, 2000, pp. 715-8.
Zullo A, Rinaldi V, Winn S, et al. A new highly effective short-term therapy schedule for Helicobacter pylori eradication. Aliment Pharmacol Ther. 2000;14(6):715-8.
Zullo, A., Rinaldi, V., Winn, S., Meddi, P., Lionetti, R., Hassan, C., ... Attili, A. F. (2000). A new highly effective short-term therapy schedule for Helicobacter pylori eradication. Alimentary Pharmacology & Therapeutics, 14(6), pp. 715-8.
Zullo A, et al. A New Highly Effective Short-term Therapy Schedule for Helicobacter Pylori Eradication. Aliment Pharmacol Ther. 2000;14(6):715-8. PubMed PMID: 10848654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new highly effective short-term therapy schedule for Helicobacter pylori eradication. AU - Zullo,A, AU - Rinaldi,V, AU - Winn,S, AU - Meddi,P, AU - Lionetti,R, AU - Hassan,C, AU - Ripani,C, AU - Tomaselli,G, AU - Attili,A F, PY - 2000/6/10/pubmed PY - 2000/8/6/medline PY - 2000/6/10/entrez SP - 715 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 14 IS - 6 N2 - BACKGROUND: Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%). AIM: To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication. METHODS: A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or 13C urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended. RESULTS: All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects. CONCLUSIONS: The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10848654/A_new_highly_effective_short_term_therapy_schedule_for_Helicobacter_pylori_eradication_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2000&amp;volume=14&amp;issue=6&amp;spage=715 DB - PRIME DP - Unbound Medicine ER -