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A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase.
Bone Marrow Transplant. 2000 Jun; 25(11):1209-11.BM

Abstract

We report here a case of donor cell leukemia in a female Ph-positive CML patient who received an allogeneic BMT from her HLA-identical brother in the chronic phase and subsequently developed a donor cell Ph-positive ALL. The number of cases of donor cell leukemia after BMT so far reported is less than 20 and in this case, as in the first cases reported by Marmont et aland McCane et al, the original leukemia and donor cell leukemia share the presence of a Ph chromosome. Furthermore, we analyzed the patient during different stages of her disease by RT-PCR and determined the type of bcr-abl junctions (M bcr-abl junction; b3a2 transcript, p210) in both the recipient and donor cell leukemia.

Authors+Show Affiliations

The Third Department of Internal Medicine, School of Medicine, Tohoku University, Aobaku, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10849535

Citation

Saito, Y, et al. "A Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia of Donor Origin After Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase." Bone Marrow Transplantation, vol. 25, no. 11, 2000, pp. 1209-11.
Saito Y, Uzuka Y, Sakai N, et al. A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Bone Marrow Transplant. 2000;25(11):1209-11.
Saito, Y., Uzuka, Y., Sakai, N., Suzuki, S., & Toyota, T. (2000). A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Bone Marrow Transplantation, 25(11), 1209-11.
Saito Y, et al. A Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia of Donor Origin After Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase. Bone Marrow Transplant. 2000;25(11):1209-11. PubMed PMID: 10849535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase. AU - Saito,Y, AU - Uzuka,Y, AU - Sakai,N, AU - Suzuki,S, AU - Toyota,T, PY - 2000/6/13/pubmed PY - 2000/7/25/medline PY - 2000/6/13/entrez SP - 1209 EP - 11 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 25 IS - 11 N2 - We report here a case of donor cell leukemia in a female Ph-positive CML patient who received an allogeneic BMT from her HLA-identical brother in the chronic phase and subsequently developed a donor cell Ph-positive ALL. The number of cases of donor cell leukemia after BMT so far reported is less than 20 and in this case, as in the first cases reported by Marmont et aland McCane et al, the original leukemia and donor cell leukemia share the presence of a Ph chromosome. Furthermore, we analyzed the patient during different stages of her disease by RT-PCR and determined the type of bcr-abl junctions (M bcr-abl junction; b3a2 transcript, p210) in both the recipient and donor cell leukemia. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/10849535/A_Philadelphia_chromosome_positive_acute_lymphoblastic_leukemia_of_donor_origin_after_allogeneic_bone_marrow_transplantation_for_chronic_myelogenous_leukemia_in_chronic_phase_ L2 - https://doi.org/10.1038/sj.bmt.1702418 DB - PRIME DP - Unbound Medicine ER -