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Antioxidant capacity and oxygen radical diseases in the preterm newborn.

Abstract

BACKGROUND

Bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy of prematurity may be different manifestations of oxygen radical diseases of prematurity (ORDP).

OBJECTIVE

To test the hypothesis that the antioxidant capacity of cord blood serum will predict risk of ORDP.

DESIGN

An inception cohort of premature neonates was followed up from birth until discharge or death to determine if outcome was related to cord blood serum antioxidant capacity, as determined by a manual assay measuring the relative inhibition of oxidation of 2,2'-azino-di-(3-ethylbenzthiazoline)-6 sulfonic acid (ABTS). Possible correlations between antioxidant capacity and various perinatal factors were also tested.

SETTING

Level 3 newborn intensive care unit.

PATIENTS

All inborn very low-birth-weight neonates from whom cord blood was available and for whom maternal consent was obtained were included. Newborns who died in the first week of life or who had major congenital malformations were excluded. A convenience sample of newborns weighing more than 1500 g was used to perfect assay and explore confounders.

MAIN OUTCOME MEASURES

Significant ORDP was defined as the presence of intraventricular hemorrhage greater than grade 2, retinopathy of prematurity greater than stage 1, bronchopulmonary dysplasia at the postconceptional age of 36 weeks, or necrotizing enterocolitis with the hypothesis that neonates with ORDP will have lower antioxidant capacity in cord blood serum.

RESULTS

Serum antioxidant capacity at birth correlated with gestational age for the entire sample of 41 neonates and for the 26 neonates born before 32 weeks' gestation. After correction for gestational age, cord serum antioxidant capacity did not correlate with maternal smoking, preeclampsia, chorioamnionitis, cord pH Apgar scores, or any of the ORDP studied.

CONCLUSION

Cord serum antioxidant capacity correlates with gestational age but does not predict ORDP risk.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School and St Peter's University Hospital, New Brunswick 08903, USA.

    , , ,

    Source

    MeSH

    Antioxidants
    Female
    Fetal Blood
    Free Radicals
    Gestational Age
    Humans
    Infant, Newborn
    Infant, Premature
    Infant, Premature, Diseases
    Male
    Reactive Oxygen Species
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10850499

    Citation

    Rogers, S, et al. "Antioxidant Capacity and Oxygen Radical Diseases in the Preterm Newborn." Archives of Pediatrics & Adolescent Medicine, vol. 154, no. 6, 2000, pp. 544-8.
    Rogers S, Witz G, Anwar M, et al. Antioxidant capacity and oxygen radical diseases in the preterm newborn. Arch Pediatr Adolesc Med. 2000;154(6):544-8.
    Rogers, S., Witz, G., Anwar, M., Hiatt, M., & Hegyi, T. (2000). Antioxidant capacity and oxygen radical diseases in the preterm newborn. Archives of Pediatrics & Adolescent Medicine, 154(6), pp. 544-8.
    Rogers S, et al. Antioxidant Capacity and Oxygen Radical Diseases in the Preterm Newborn. Arch Pediatr Adolesc Med. 2000;154(6):544-8. PubMed PMID: 10850499.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant capacity and oxygen radical diseases in the preterm newborn. AU - Rogers,S, AU - Witz,G, AU - Anwar,M, AU - Hiatt,M, AU - Hegyi,T, PY - 2000/6/13/pubmed PY - 2000/6/24/medline PY - 2000/6/13/entrez SP - 544 EP - 8 JF - Archives of pediatrics & adolescent medicine JO - Arch Pediatr Adolesc Med VL - 154 IS - 6 N2 - BACKGROUND: Bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy of prematurity may be different manifestations of oxygen radical diseases of prematurity (ORDP). OBJECTIVE: To test the hypothesis that the antioxidant capacity of cord blood serum will predict risk of ORDP. DESIGN: An inception cohort of premature neonates was followed up from birth until discharge or death to determine if outcome was related to cord blood serum antioxidant capacity, as determined by a manual assay measuring the relative inhibition of oxidation of 2,2'-azino-di-(3-ethylbenzthiazoline)-6 sulfonic acid (ABTS). Possible correlations between antioxidant capacity and various perinatal factors were also tested. SETTING: Level 3 newborn intensive care unit. PATIENTS: All inborn very low-birth-weight neonates from whom cord blood was available and for whom maternal consent was obtained were included. Newborns who died in the first week of life or who had major congenital malformations were excluded. A convenience sample of newborns weighing more than 1500 g was used to perfect assay and explore confounders. MAIN OUTCOME MEASURES: Significant ORDP was defined as the presence of intraventricular hemorrhage greater than grade 2, retinopathy of prematurity greater than stage 1, bronchopulmonary dysplasia at the postconceptional age of 36 weeks, or necrotizing enterocolitis with the hypothesis that neonates with ORDP will have lower antioxidant capacity in cord blood serum. RESULTS: Serum antioxidant capacity at birth correlated with gestational age for the entire sample of 41 neonates and for the 26 neonates born before 32 weeks' gestation. After correction for gestational age, cord serum antioxidant capacity did not correlate with maternal smoking, preeclampsia, chorioamnionitis, cord pH Apgar scores, or any of the ORDP studied. CONCLUSION: Cord serum antioxidant capacity correlates with gestational age but does not predict ORDP risk. SN - 1072-4710 UR - https://www.unboundmedicine.com/medline/citation/10850499/Antioxidant_capacity_and_oxygen_radical_diseases_in_the_preterm_newborn_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/vol/154/pg/544 DB - PRIME DP - Unbound Medicine ER -