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Clinical and epidemiological patterns of Argentine haemorrhagic fever.
Bull World Health Organ. 1975; 52(4-6):567-75.BW

Abstract

The epidemiology of Argentine haemorrhagic fever (AHF) is closely related to cricetine rodents acting as natural hosts of Junin virus. The endemo-epidemic area, which has increased 5 times since the disease was first recognized 15-20 years ago, is located in a densely populated region of Argentina. It has been shown that the virus of LCM is active in humans and rodents of the AHF endemic area; this demonstrates the simultaneous presence of two arenaviruses pathogenic for man in a given geographic location.The disease is characterized by haematological, renal, neurological and cardiovascular changes. Electron microscopy and immunohistochemical studies have shown cytopathic changes, characteristic intracellular virus-like particles, and antigenic determinants of Junin virus in different organs from 9 cases of AHF. No deposits of immunoglobulins or C3 were found in the kidneys; in addition, an absence of fibrinogen and C3 in the hepatocytes and of immunoglobulins in the spleen was observed. These findings suggest a direct viral pathogenic action in the human disease.Ultrastructural and immunofluorescence studies in tissues of guinea-pigs inoculated with two strains of Junin virus revealed the presence of the same types of virus-like particles and antigenic determinants of Junin virus as were encountered in the human subjects with AHF.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1085212

Citation

Maiztegui, J I.. "Clinical and Epidemiological Patterns of Argentine Haemorrhagic Fever." Bulletin of the World Health Organization, vol. 52, no. 4-6, 1975, pp. 567-75.
Maiztegui JI. Clinical and epidemiological patterns of Argentine haemorrhagic fever. Bull World Health Organ. 1975;52(4-6):567-75.
Maiztegui, J. I. (1975). Clinical and epidemiological patterns of Argentine haemorrhagic fever. Bulletin of the World Health Organization, 52(4-6), 567-75.
Maiztegui JI. Clinical and Epidemiological Patterns of Argentine Haemorrhagic Fever. Bull World Health Organ. 1975;52(4-6):567-75. PubMed PMID: 1085212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and epidemiological patterns of Argentine haemorrhagic fever. A1 - Maiztegui,J I, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 567 EP - 75 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 52 IS - 4-6 N2 - The epidemiology of Argentine haemorrhagic fever (AHF) is closely related to cricetine rodents acting as natural hosts of Junin virus. The endemo-epidemic area, which has increased 5 times since the disease was first recognized 15-20 years ago, is located in a densely populated region of Argentina. It has been shown that the virus of LCM is active in humans and rodents of the AHF endemic area; this demonstrates the simultaneous presence of two arenaviruses pathogenic for man in a given geographic location.The disease is characterized by haematological, renal, neurological and cardiovascular changes. Electron microscopy and immunohistochemical studies have shown cytopathic changes, characteristic intracellular virus-like particles, and antigenic determinants of Junin virus in different organs from 9 cases of AHF. No deposits of immunoglobulins or C3 were found in the kidneys; in addition, an absence of fibrinogen and C3 in the hepatocytes and of immunoglobulins in the spleen was observed. These findings suggest a direct viral pathogenic action in the human disease.Ultrastructural and immunofluorescence studies in tissues of guinea-pigs inoculated with two strains of Junin virus revealed the presence of the same types of virus-like particles and antigenic determinants of Junin virus as were encountered in the human subjects with AHF. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/1085212/Clinical_and_epidemiological_patterns_of_Argentine_haemorrhagic_fever_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1085212/ DB - PRIME DP - Unbound Medicine ER -