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The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study.
J Rheumatol. 2000 Jun; 27(6):1501-5.JR

Abstract

OBJECTIVE

To investigate the incidence of gout and the interaction between uric acid level and other risk factors in the development of gout.

METHODS

Two hundred twenty-three asymptomatic hyperuricemic men initially studied in 1991-92 were reassessed in 1996-97. Gout was clinically diagnosed by a senior rheumatologist based on history and physical according to the clinical criteria of Wallace. Basic demographic and lifestyle variables as well as biochemical data were collected in both baseline and followup periods. Both the stability analysis and the analysis of repeated relationships were applied.

RESULTS

The 5-year cumulative incidence of gout was 18.83% (42/223). The risk factors for gout based on the analysis of repeated relationships were uric acid level, alcohol consumption, use of diuretics, and obesity. The only predictor of gout at baseline was uric acid level. After adjusting for baseline uric acid level, followup uric acid increase, persistent alcohol consumption, use of diuretics in the followup period, and body mass index increase were independent predictors for gout among asymptomatic hyperuricemic men. Excessive alcohol consumption, particularly if occasional, was the most important factor in the development of gout, even when the concentration of uric acid level was below 8 mg/dl.

CONCLUSION

Uric acid level is the key factor for prevention of gout and needs constant monitoring. Other contributing or possible etiologic factors such as alcohol consumption, diuretics use, and excess weight gain carry an increased risk of gout attack among patients with hyperuricemia.

Authors+Show Affiliations

Community Medicine Research Center & Institute of Public Health, National Yang-Ming University, and Veterans General Hospital, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10852278

Citation

Lin, K C., et al. "The Interaction Between Uric Acid Level and Other Risk Factors On the Development of Gout Among Asymptomatic Hyperuricemic Men in a Prospective Study." The Journal of Rheumatology, vol. 27, no. 6, 2000, pp. 1501-5.
Lin KC, Lin HY, Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J Rheumatol. 2000;27(6):1501-5.
Lin, K. C., Lin, H. Y., & Chou, P. (2000). The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. The Journal of Rheumatology, 27(6), 1501-5.
Lin KC, Lin HY, Chou P. The Interaction Between Uric Acid Level and Other Risk Factors On the Development of Gout Among Asymptomatic Hyperuricemic Men in a Prospective Study. J Rheumatol. 2000;27(6):1501-5. PubMed PMID: 10852278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. AU - Lin,K C, AU - Lin,H Y, AU - Chou,P, PY - 2000/6/14/pubmed PY - 2000/10/14/medline PY - 2000/6/14/entrez SP - 1501 EP - 5 JF - The Journal of rheumatology JO - J Rheumatol VL - 27 IS - 6 N2 - OBJECTIVE: To investigate the incidence of gout and the interaction between uric acid level and other risk factors in the development of gout. METHODS: Two hundred twenty-three asymptomatic hyperuricemic men initially studied in 1991-92 were reassessed in 1996-97. Gout was clinically diagnosed by a senior rheumatologist based on history and physical according to the clinical criteria of Wallace. Basic demographic and lifestyle variables as well as biochemical data were collected in both baseline and followup periods. Both the stability analysis and the analysis of repeated relationships were applied. RESULTS: The 5-year cumulative incidence of gout was 18.83% (42/223). The risk factors for gout based on the analysis of repeated relationships were uric acid level, alcohol consumption, use of diuretics, and obesity. The only predictor of gout at baseline was uric acid level. After adjusting for baseline uric acid level, followup uric acid increase, persistent alcohol consumption, use of diuretics in the followup period, and body mass index increase were independent predictors for gout among asymptomatic hyperuricemic men. Excessive alcohol consumption, particularly if occasional, was the most important factor in the development of gout, even when the concentration of uric acid level was below 8 mg/dl. CONCLUSION: Uric acid level is the key factor for prevention of gout and needs constant monitoring. Other contributing or possible etiologic factors such as alcohol consumption, diuretics use, and excess weight gain carry an increased risk of gout attack among patients with hyperuricemia. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/10852278/The_interaction_between_uric_acid_level_and_other_risk_factors_on_the_development_of_gout_among_asymptomatic_hyperuricemic_men_in_a_prospective_study_ L2 - https://medlineplus.gov/gout.html DB - PRIME DP - Unbound Medicine ER -