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Regional brain atrophy in progressive supranuclear palsy and Lewy body disease.
Ann Neurol. 2000 Jun; 47(6):718-28.AN

Abstract

There have been no previous three-dimensional volumetric studies of regional brain atrophy in patients with pathologically confirmed progressive supranuclear palsy (PSP). Postmortem cortical and subcortical volumes were compared with neuropathology in 9 patients with PSP, 15 patients with Parkinson's disease, 10 patients with dementia with Lewy bodies, and 23 controls. Cases with the neuritic pathology of Alzheimer's disease were excluded. The topography of brain atrophy differed according to clinicopathological phenotype. Patients with Parkinson's disease had atrophy confined to the amygdala. Atrophy of the frontal lobe was found in both PSP and dementia with Lewy bodies and correlated with increasing neurofibrillary tangle or Lewy body densities, respectively. Patients with PSP could be differentiated by their marked atrophy of the internal globus pallidus. Further analysis of variance revealed that trends for greater frontal lobe atrophy correlated with clinical dementia in PSP, whereas both greater frontal and hippocampal atrophy and higher densities of Lewy bodies and Lewy neurites correlated with clinical dementia in cases with Lewy bodies. The present study provides evidence for selective regional atrophy that correlates with the underlying pathology of PSP and Lewy body disease.

Authors+Show Affiliations

Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10852537

Citation

Cordato, N J., et al. "Regional Brain Atrophy in Progressive Supranuclear Palsy and Lewy Body Disease." Annals of Neurology, vol. 47, no. 6, 2000, pp. 718-28.
Cordato NJ, Halliday GM, Harding AJ, et al. Regional brain atrophy in progressive supranuclear palsy and Lewy body disease. Ann Neurol. 2000;47(6):718-28.
Cordato, N. J., Halliday, G. M., Harding, A. J., Hely, M. A., & Morris, J. G. (2000). Regional brain atrophy in progressive supranuclear palsy and Lewy body disease. Annals of Neurology, 47(6), 718-28.
Cordato NJ, et al. Regional Brain Atrophy in Progressive Supranuclear Palsy and Lewy Body Disease. Ann Neurol. 2000;47(6):718-28. PubMed PMID: 10852537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional brain atrophy in progressive supranuclear palsy and Lewy body disease. AU - Cordato,N J, AU - Halliday,G M, AU - Harding,A J, AU - Hely,M A, AU - Morris,J G, PY - 2000/6/14/pubmed PY - 2000/7/6/medline PY - 2000/6/14/entrez SP - 718 EP - 28 JF - Annals of neurology JO - Ann Neurol VL - 47 IS - 6 N2 - There have been no previous three-dimensional volumetric studies of regional brain atrophy in patients with pathologically confirmed progressive supranuclear palsy (PSP). Postmortem cortical and subcortical volumes were compared with neuropathology in 9 patients with PSP, 15 patients with Parkinson's disease, 10 patients with dementia with Lewy bodies, and 23 controls. Cases with the neuritic pathology of Alzheimer's disease were excluded. The topography of brain atrophy differed according to clinicopathological phenotype. Patients with Parkinson's disease had atrophy confined to the amygdala. Atrophy of the frontal lobe was found in both PSP and dementia with Lewy bodies and correlated with increasing neurofibrillary tangle or Lewy body densities, respectively. Patients with PSP could be differentiated by their marked atrophy of the internal globus pallidus. Further analysis of variance revealed that trends for greater frontal lobe atrophy correlated with clinical dementia in PSP, whereas both greater frontal and hippocampal atrophy and higher densities of Lewy bodies and Lewy neurites correlated with clinical dementia in cases with Lewy bodies. The present study provides evidence for selective regional atrophy that correlates with the underlying pathology of PSP and Lewy body disease. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/10852537/Regional_brain_atrophy_in_progressive_supranuclear_palsy_and_Lewy_body_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2000&volume=47&issue=6&spage=718 DB - PRIME DP - Unbound Medicine ER -