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Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers.
Pharmacotherapy. 2000 Jun; 20(6):657-61.P

Abstract

STUDY OBJECTIVE

To compare serum and intracellular pharmacokinetics of azithromycin in healthy volunteers and patients with diabetes.

DESIGN

Open-label, parallel study.

SETTING

Clinical research center.

SUBJECTS

Twelve patients with diabetes and 12 healthy volunteers.

INTERVENTIONS

Subjects were given a single 500-mg dose of azithromycin followed by 250 mg/day for 2 days. Blood samples were obtained just before and after the third dose for up to 24 hours for serum and 168 hours for intracellular measurement of azithromycin.

MEASUREMENTS AND MAIN RESULTS

Pharmacokinetic parameters were calculated by noncompartmental methods and compared with a t test. The groups did not differ in maximum concentration, time to maximum concentration, or area under the concentration-time curve in serum or polymorphonuclear cells (PMNs). Differences in the PMN:serum ratio were observed at the 24-hour time point (healthy 1209 +/- 432, diabetic 859 +/- 286, p=0.051).

CONCLUSION

In general, the pharmacokinetics of azithromycin are comparable in diabetics and healthy volunteers. Accumulation of drug in macrophages was slightly lower in patients.

Authors+Show Affiliations

Division of Clinical and Administrative Pharmacy, University of Iowa, College of Pharmacy, Iowa City 52242, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10853621

Citation

Ernst, E J., et al. "Comparison of the Serum and Intracellular Pharmacokinetics of Azithromycin in Healthy and Diabetic Volunteers." Pharmacotherapy, vol. 20, no. 6, 2000, pp. 657-61.
Ernst EJ, Klepser ME, Klepser TB, et al. Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers. Pharmacotherapy. 2000;20(6):657-61.
Ernst, E. J., Klepser, M. E., Klepser, T. B., Nightingale, C. H., & Hunsicker, L. G. (2000). Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers. Pharmacotherapy, 20(6), 657-61.
Ernst EJ, et al. Comparison of the Serum and Intracellular Pharmacokinetics of Azithromycin in Healthy and Diabetic Volunteers. Pharmacotherapy. 2000;20(6):657-61. PubMed PMID: 10853621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers. AU - Ernst,E J, AU - Klepser,M E, AU - Klepser,T B, AU - Nightingale,C H, AU - Hunsicker,L G, PY - 2000/6/15/pubmed PY - 2000/9/30/medline PY - 2000/6/15/entrez SP - 657 EP - 61 JF - Pharmacotherapy JO - Pharmacotherapy VL - 20 IS - 6 N2 - STUDY OBJECTIVE: To compare serum and intracellular pharmacokinetics of azithromycin in healthy volunteers and patients with diabetes. DESIGN: Open-label, parallel study. SETTING: Clinical research center. SUBJECTS: Twelve patients with diabetes and 12 healthy volunteers. INTERVENTIONS: Subjects were given a single 500-mg dose of azithromycin followed by 250 mg/day for 2 days. Blood samples were obtained just before and after the third dose for up to 24 hours for serum and 168 hours for intracellular measurement of azithromycin. MEASUREMENTS AND MAIN RESULTS: Pharmacokinetic parameters were calculated by noncompartmental methods and compared with a t test. The groups did not differ in maximum concentration, time to maximum concentration, or area under the concentration-time curve in serum or polymorphonuclear cells (PMNs). Differences in the PMN:serum ratio were observed at the 24-hour time point (healthy 1209 +/- 432, diabetic 859 +/- 286, p=0.051). CONCLUSION: In general, the pharmacokinetics of azithromycin are comparable in diabetics and healthy volunteers. Accumulation of drug in macrophages was slightly lower in patients. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/10853621/Comparison_of_the_serum_and_intracellular_pharmacokinetics_of_azithromycin_in_healthy_and_diabetic_volunteers_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0277-0008&date=2000&volume=20&issue=6&spage=657 DB - PRIME DP - Unbound Medicine ER -