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Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
Eur J Pharmacol. 2000 Jun 16; 398(2):251-8.EJ

Abstract

We examined the effects of Delta 9-tetrahydrocannabinol (Delta 9-THC), (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide ((R)-methanandamide, AM 356), SR 141716, and d-amphetamine on fixed-ratio (FR) responding maintained by food in rats before and during daily dosing with Delta 9-THC. Rats responded under a FR 10 schedule of food reinforcement. Cumulative dose-response curves for the various drugs were determined before and during daily Delta 9-THC administration. All four drugs dose-dependently decreased responding both before and during daily dosing with Delta 9-THC (18 mg/kg/day). The dose-response curves for both Delta 9-THC and (R)-methanandamide were shifted to the right with daily dosing with Delta 9-THC, indicating tolerance to the effects of Delta 9-THC and cross-tolerance to the effects of (R)-methanandamide. The doses of d-amphetamine examined produced similar effects both before and during daily dosing with Delta 9-THC. The effects of SR 141716 were not consistently altered by daily Delta 9-THC administration. These results indicate that tolerance develops to the effects of Delta 9-THC, when Delta 9-THC is administered repeatedly. These results also indicate that cross-tolerance to (R)-methanandamide develops with repeated Delta 9-THC administration.

Authors+Show Affiliations

Departments of Psychiatry and Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. lamb@uthscsa.edunNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10854837

Citation

Lamb, R J., et al. "Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and D-amphetamine Before and During Daily Delta 9-tetrahydrocannabinol Dosing." European Journal of Pharmacology, vol. 398, no. 2, 2000, pp. 251-8.
Lamb RJ, Järbe TU, Makriyannis A, et al. Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. Eur J Pharmacol. 2000;398(2):251-8.
Lamb, R. J., Järbe, T. U., Makriyannis, A., Lin, S., & Goutopoulos, A. (2000). Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. European Journal of Pharmacology, 398(2), 251-8.
Lamb RJ, et al. Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and D-amphetamine Before and During Daily Delta 9-tetrahydrocannabinol Dosing. Eur J Pharmacol. 2000 Jun 16;398(2):251-8. PubMed PMID: 10854837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. AU - Lamb,R J, AU - Järbe,T U, AU - Makriyannis,A, AU - Lin,S, AU - Goutopoulos,A, PY - 2000/6/16/pubmed PY - 2000/10/7/medline PY - 2000/6/16/entrez SP - 251 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 398 IS - 2 N2 - We examined the effects of Delta 9-tetrahydrocannabinol (Delta 9-THC), (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide ((R)-methanandamide, AM 356), SR 141716, and d-amphetamine on fixed-ratio (FR) responding maintained by food in rats before and during daily dosing with Delta 9-THC. Rats responded under a FR 10 schedule of food reinforcement. Cumulative dose-response curves for the various drugs were determined before and during daily Delta 9-THC administration. All four drugs dose-dependently decreased responding both before and during daily dosing with Delta 9-THC (18 mg/kg/day). The dose-response curves for both Delta 9-THC and (R)-methanandamide were shifted to the right with daily dosing with Delta 9-THC, indicating tolerance to the effects of Delta 9-THC and cross-tolerance to the effects of (R)-methanandamide. The doses of d-amphetamine examined produced similar effects both before and during daily dosing with Delta 9-THC. The effects of SR 141716 were not consistently altered by daily Delta 9-THC administration. These results indicate that tolerance develops to the effects of Delta 9-THC, when Delta 9-THC is administered repeatedly. These results also indicate that cross-tolerance to (R)-methanandamide develops with repeated Delta 9-THC administration. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/10854837/Effects_of_Delta_9_tetrahydrocannabinol__R__methanandamide_SR_141716and_d_amphetamine_before_and_during_daily_Delta_9_tetrahydrocannabinol_dosing_ DB - PRIME DP - Unbound Medicine ER -