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Nephrotic-range proteinuria, the major risk factor for early atherosclerosis in juvenile-onset systemic lupus erythematosus.
Arthritis Rheum 2000; 43(6):1405-9AR

Abstract

OBJECTIVE

To determine the presence of early carotid atherosclerosis and associated risk factors in patients with juvenile-onset systemic lupus erythematosus (SLE).

METHODS

The carotid intima-media wall thickness (IMT) was measured by B-mode ultrasound in patients with SLE onset before the age of 16 years and in sex- and age-matched healthy control subjects. Risk factors for atherosclerosis were determined at the time of the ultrasound scan and included traditional cardiovascular and SLE-related risk factors.

RESULTS

Twenty-six patients with juvenile-onset SLE and 26 healthy controls were studied. The mean (+/- SD) IMT of the SLE patients was significantly higher than that of the control group (0.57+/-0.05 mm and 0.54+/-0.03 mm, respectively; P = 0.006). The results of IMT measurement were not correlated with the patients' age, disease duration, SLE Disease Activity Index (SLEDAI) score, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (DI) score, laboratory indicators of lupus activity, or cumulative prednisone dose. Patients with nephrotic-range (NR) proteinuria (> or = 3.5 gm/24 hours; n = 6) had a significantly higher IMT than did those without (n = 20) (P = 0.02). Patients with NR proteinuria also had significantly higher SLEDAI scores, SLICC/ACR DI scores, and systolic and diastolic blood pressures, and significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and fibrinogen. No difference in any of the above variables, including the IMT, was observed when SLE patients without NR proteinuria were compared with healthy controls.

CONCLUSION

These patients with juvenile-onset SLE had ultrasonographic evidence of premature atherosclerosis. The risk of early atherosclerosis may be higher in patients with NR proteinuria.

Authors+Show Affiliations

Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, Pavia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10857801

Citation

Falaschi, F, et al. "Nephrotic-range Proteinuria, the Major Risk Factor for Early Atherosclerosis in Juvenile-onset Systemic Lupus Erythematosus." Arthritis and Rheumatism, vol. 43, no. 6, 2000, pp. 1405-9.
Falaschi F, Ravelli A, Martignoni A, et al. Nephrotic-range proteinuria, the major risk factor for early atherosclerosis in juvenile-onset systemic lupus erythematosus. Arthritis Rheum. 2000;43(6):1405-9.
Falaschi, F., Ravelli, A., Martignoni, A., Migliavacca, D., Sartori, M., Pistorio, A., ... Martini, A. (2000). Nephrotic-range proteinuria, the major risk factor for early atherosclerosis in juvenile-onset systemic lupus erythematosus. Arthritis and Rheumatism, 43(6), pp. 1405-9.
Falaschi F, et al. Nephrotic-range Proteinuria, the Major Risk Factor for Early Atherosclerosis in Juvenile-onset Systemic Lupus Erythematosus. Arthritis Rheum. 2000;43(6):1405-9. PubMed PMID: 10857801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephrotic-range proteinuria, the major risk factor for early atherosclerosis in juvenile-onset systemic lupus erythematosus. AU - Falaschi,F, AU - Ravelli,A, AU - Martignoni,A, AU - Migliavacca,D, AU - Sartori,M, AU - Pistorio,A, AU - Perani,G, AU - Martini,A, PY - 2000/6/17/pubmed PY - 2000/7/8/medline PY - 2000/6/17/entrez SP - 1405 EP - 9 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 43 IS - 6 N2 - OBJECTIVE: To determine the presence of early carotid atherosclerosis and associated risk factors in patients with juvenile-onset systemic lupus erythematosus (SLE). METHODS: The carotid intima-media wall thickness (IMT) was measured by B-mode ultrasound in patients with SLE onset before the age of 16 years and in sex- and age-matched healthy control subjects. Risk factors for atherosclerosis were determined at the time of the ultrasound scan and included traditional cardiovascular and SLE-related risk factors. RESULTS: Twenty-six patients with juvenile-onset SLE and 26 healthy controls were studied. The mean (+/- SD) IMT of the SLE patients was significantly higher than that of the control group (0.57+/-0.05 mm and 0.54+/-0.03 mm, respectively; P = 0.006). The results of IMT measurement were not correlated with the patients' age, disease duration, SLE Disease Activity Index (SLEDAI) score, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (DI) score, laboratory indicators of lupus activity, or cumulative prednisone dose. Patients with nephrotic-range (NR) proteinuria (> or = 3.5 gm/24 hours; n = 6) had a significantly higher IMT than did those without (n = 20) (P = 0.02). Patients with NR proteinuria also had significantly higher SLEDAI scores, SLICC/ACR DI scores, and systolic and diastolic blood pressures, and significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and fibrinogen. No difference in any of the above variables, including the IMT, was observed when SLE patients without NR proteinuria were compared with healthy controls. CONCLUSION: These patients with juvenile-onset SLE had ultrasonographic evidence of premature atherosclerosis. The risk of early atherosclerosis may be higher in patients with NR proteinuria. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/10857801/Nephrotic_range_proteinuria_the_major_risk_factor_for_early_atherosclerosis_in_juvenile_onset_systemic_lupus_erythematosus_ L2 - https://doi.org/10.1002/1529-0131(200006)43:6<1405::AID-ANR26>3.0.CO;2-V DB - PRIME DP - Unbound Medicine ER -