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The type of dietary fat alters the hepatic uptake and biliary excretion of cholesterol from chylomicron remnants.
Br J Nutr. 2000 Apr; 83(4):431-8.BJ

Abstract

The consumption of fat-enriched diets may alter the uptake and metabolism of chylomicron remnant cholesterol by the liver. To test this hypothesis, [3H]cholesterol-labelled chylomicron remnants derived from different dietary fats were studied in perfused livers both from rats fed on diets enriched in the corresponding fats and from rats fed on a low-fat diet. Livers from rats fed on each of the fat-enriched diets removed similar amounts (34-40%) of the [3H]cholesterol-labelled remnants added, whereas livers from rats fed on the low-fat diet removed significantly more labelled fish-oil and butter-fat remnants than olive-, maize- or palm-oil remnants. Significantly more remnant [3H]cholesterol was secreted into the perfusate HDL by livers from rats fed on the olive-oil, fish-oil and butter-fat diets when compared with those from rats fed on the low-fat diet or the maize-oil diet. Furthermore, the excretion of remnant [3H]cholesterol via the bile acid was increased by the olive-, maize-, palm- or fish-oil diets, and decreased by the butter-fat diet when compared with the low-fat diet, although the [3H]bile acid excreted remained less on saturated fat diets. This investigation shows that the hepatic uptake and subsequent metabolism of cholesterol from chylomicron remnants is influenced by the type of fat in the diet as well as the fatty acid composition of the particles themselves, and may help to explain some of the hyper- and hypocholesterolaemic effects of saturated and unsaturated fatty acids.

Authors+Show Affiliations

Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, UK. mlambert@rvc.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10858701

Citation

Lambert, M S., et al. "The Type of Dietary Fat Alters the Hepatic Uptake and Biliary Excretion of Cholesterol From Chylomicron Remnants." The British Journal of Nutrition, vol. 83, no. 4, 2000, pp. 431-8.
Lambert MS, Avella MA, Botham KM, et al. The type of dietary fat alters the hepatic uptake and biliary excretion of cholesterol from chylomicron remnants. Br J Nutr. 2000;83(4):431-8.
Lambert, M. S., Avella, M. A., Botham, K. M., & Mayes, P. A. (2000). The type of dietary fat alters the hepatic uptake and biliary excretion of cholesterol from chylomicron remnants. The British Journal of Nutrition, 83(4), 431-8.
Lambert MS, et al. The Type of Dietary Fat Alters the Hepatic Uptake and Biliary Excretion of Cholesterol From Chylomicron Remnants. Br J Nutr. 2000;83(4):431-8. PubMed PMID: 10858701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The type of dietary fat alters the hepatic uptake and biliary excretion of cholesterol from chylomicron remnants. AU - Lambert,M S, AU - Avella,M A, AU - Botham,K M, AU - Mayes,P A, PY - 2000/6/20/pubmed PY - 2000/7/6/medline PY - 2000/6/20/entrez SP - 431 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 83 IS - 4 N2 - The consumption of fat-enriched diets may alter the uptake and metabolism of chylomicron remnant cholesterol by the liver. To test this hypothesis, [3H]cholesterol-labelled chylomicron remnants derived from different dietary fats were studied in perfused livers both from rats fed on diets enriched in the corresponding fats and from rats fed on a low-fat diet. Livers from rats fed on each of the fat-enriched diets removed similar amounts (34-40%) of the [3H]cholesterol-labelled remnants added, whereas livers from rats fed on the low-fat diet removed significantly more labelled fish-oil and butter-fat remnants than olive-, maize- or palm-oil remnants. Significantly more remnant [3H]cholesterol was secreted into the perfusate HDL by livers from rats fed on the olive-oil, fish-oil and butter-fat diets when compared with those from rats fed on the low-fat diet or the maize-oil diet. Furthermore, the excretion of remnant [3H]cholesterol via the bile acid was increased by the olive-, maize-, palm- or fish-oil diets, and decreased by the butter-fat diet when compared with the low-fat diet, although the [3H]bile acid excreted remained less on saturated fat diets. This investigation shows that the hepatic uptake and subsequent metabolism of cholesterol from chylomicron remnants is influenced by the type of fat in the diet as well as the fatty acid composition of the particles themselves, and may help to explain some of the hyper- and hypocholesterolaemic effects of saturated and unsaturated fatty acids. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10858701/The_type_of_dietary_fat_alters_the_hepatic_uptake_and_biliary_excretion_of_cholesterol_from_chylomicron_remnants_ L2 - https://www.cambridge.org/core/product/identifier/S0007114500000532/type/journal_article DB - PRIME DP - Unbound Medicine ER -