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Several selective protein kinase C inhibitors including procyanidins promote hair growth.
Skin Pharmacol Appl Skin Physiol. 2000 May-Aug; 13(3-4):133-42.SP

Abstract

We have previously reported that procyanidin oligomers selectively promote growth of murine hair epithelial cells in vitro and stimulate anagen induction in vivo. We report here the possible relationship between the protein kinase C-inhibiting activity of procyanidins and their hair-growing activity. Of the procyanidins, procyanidin B-2 and procyanidin C-1, which selectively inhibit protein kinase C, intensively promote hair epithelial cell proliferation in vitro and stimulate anagen induction in vivo. On the other hand, procyanidins, which inhibit both protein kinase C and A, showed relatively low activity in in vitro and in vivo evaluations. We also found that calphostin C, which is a selective inhibitor of protein kinase C, possesses hair epithelial cell growth-promoting activity in vitro and anagen phase-inducing hair-growing activity in vivo. Other selective protein kinase C inhibitors, such as hexadecylphosphocholine, palmitoyl-DL-carnitine chloride, and polymyxin B sulfate, also show marked anagen phase-inducing hair-growing activity in vivo. Nonselective protein kinase inhibitors, such as staurosporine and K252a, inhibit the growth of hair epithelial cells. 1,2-Dioctanoyl-sn-glycerol, a protein kinase C activator, dose-dependently decreases the growth of hair epithelial cells. Forskolin, an adenylate cyclase activator, promotes hair epithelial cell growth and boosts the growth-promoting effect of procyanidin B-2. It is speculated that the hair-growing activity of procyanidins is related to their protein kinase C-inhibiting activity.

Authors+Show Affiliations

Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Tsukuba, Ibaraki, Japan. tomoya.takahashi@kyowa.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10859531

Citation

Takahashi, T, et al. "Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth." Skin Pharmacology and Applied Skin Physiology, vol. 13, no. 3-4, 2000, pp. 133-42.
Takahashi T, Kamimura A, Shirai A, et al. Several selective protein kinase C inhibitors including procyanidins promote hair growth. Skin Pharmacol Appl Skin Physiol. 2000;13(3-4):133-42.
Takahashi, T., Kamimura, A., Shirai, A., & Yokoo, Y. (2000). Several selective protein kinase C inhibitors including procyanidins promote hair growth. Skin Pharmacology and Applied Skin Physiology, 13(3-4), 133-42.
Takahashi T, et al. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth. Skin Pharmacol Appl Skin Physiol. 2000 May-Aug;13(3-4):133-42. PubMed PMID: 10859531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Several selective protein kinase C inhibitors including procyanidins promote hair growth. AU - Takahashi,T, AU - Kamimura,A, AU - Shirai,A, AU - Yokoo,Y, PY - 2000/6/22/pubmed PY - 2000/8/29/medline PY - 2000/6/22/entrez SP - 133 EP - 42 JF - Skin pharmacology and applied skin physiology JO - Skin Pharmacol Appl Skin Physiol VL - 13 IS - 3-4 N2 - We have previously reported that procyanidin oligomers selectively promote growth of murine hair epithelial cells in vitro and stimulate anagen induction in vivo. We report here the possible relationship between the protein kinase C-inhibiting activity of procyanidins and their hair-growing activity. Of the procyanidins, procyanidin B-2 and procyanidin C-1, which selectively inhibit protein kinase C, intensively promote hair epithelial cell proliferation in vitro and stimulate anagen induction in vivo. On the other hand, procyanidins, which inhibit both protein kinase C and A, showed relatively low activity in in vitro and in vivo evaluations. We also found that calphostin C, which is a selective inhibitor of protein kinase C, possesses hair epithelial cell growth-promoting activity in vitro and anagen phase-inducing hair-growing activity in vivo. Other selective protein kinase C inhibitors, such as hexadecylphosphocholine, palmitoyl-DL-carnitine chloride, and polymyxin B sulfate, also show marked anagen phase-inducing hair-growing activity in vivo. Nonselective protein kinase inhibitors, such as staurosporine and K252a, inhibit the growth of hair epithelial cells. 1,2-Dioctanoyl-sn-glycerol, a protein kinase C activator, dose-dependently decreases the growth of hair epithelial cells. Forskolin, an adenylate cyclase activator, promotes hair epithelial cell growth and boosts the growth-promoting effect of procyanidin B-2. It is speculated that the hair-growing activity of procyanidins is related to their protein kinase C-inhibiting activity. SN - 1422-2868 UR - https://www.unboundmedicine.com/medline/citation/10859531/Several_selective_protein_kinase_C_inhibitors_including_procyanidins_promote_hair_growth_ L2 - https://antibodies.cancer.gov/detail/CPTC-SIGLEC1-1 DB - PRIME DP - Unbound Medicine ER -