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Rapid diagnosis of falciparum malaria by detection of Plasmodium falciparum HRP-2 antigen.
J Assoc Physicians India. 1999 Nov; 47(11):1076-8.JA

Abstract

OBJECTIVE

Malaria is a resurging problem all over the country and rapid diagnosis is mandatory to decrease the morbidity and mortality and for control of malaria. In the current study the aim was to evaluate the usefulness of rapid Plasmodium falciparum antigen detection and to compare its utility over conventional peripheral thick and thin smear examination.

METHODS

Three hundred fifty seven randomly selected patients with pyrexia and or atypical presentations of malaria, found initially negative for malaria were subjected to thick and thin smear examination and Plasmodium falciparum antigen detection test by using commercially available Parasight F. kit.

RESULTS

54.6% of cases presented with pyrexia, while other presentations of falciparum malaria were less frequently encountered (162/357). Eighty five patients (23.8%) were diagnosed as having falciparum malaria based on smear/Parasight F. Test. Eighty- four of these patients were positive for Parasight F. test and only 34.51% of these cases were also positive on smear examination.

CONCLUSION

The antigen detection test for Plasmodium falciparum is useful for rapid diagnosis of Plasmodium falciparum malaria. It could detect 65.5% cases of falciparum malaria which were initially negative by peripheral smear examination. Hence, this technique is superior to peripheral smear staining and helps early diagnosis.

Authors+Show Affiliations

Pinto MJ
Dept. of Microbiology, Goa Medical College, Bambolim-Goa.
Pereira NF
No affiliation info available
Rodrigues S
No affiliation info available
Kharangate NV
No affiliation info available
Verenkar MP
No affiliation info available

MeSH

AnimalsAntigens, ProtozoanHumansMalaria, FalciparumPlasmodium falciparumPredictive Value of TestsProspective StudiesReagent Kits, Diagnostic

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10862317

Citation

Pinto, M J., et al. "Rapid Diagnosis of Falciparum Malaria By Detection of Plasmodium Falciparum HRP-2 Antigen." The Journal of the Association of Physicians of India, vol. 47, no. 11, 1999, pp. 1076-8.
Pinto MJ, Pereira NF, Rodrigues S, et al. Rapid diagnosis of falciparum malaria by detection of Plasmodium falciparum HRP-2 antigen. J Assoc Physicians India. 1999;47(11):1076-8.
Pinto, M. J., Pereira, N. F., Rodrigues, S., Kharangate, N. V., & Verenkar, M. P. (1999). Rapid diagnosis of falciparum malaria by detection of Plasmodium falciparum HRP-2 antigen. The Journal of the Association of Physicians of India, 47(11), 1076-8.
Pinto MJ, et al. Rapid Diagnosis of Falciparum Malaria By Detection of Plasmodium Falciparum HRP-2 Antigen. J Assoc Physicians India. 1999;47(11):1076-8. PubMed PMID: 10862317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid diagnosis of falciparum malaria by detection of Plasmodium falciparum HRP-2 antigen. AU - Pinto,M J, AU - Pereira,N F, AU - Rodrigues,S, AU - Kharangate,N V, AU - Verenkar,M P, PY - 2000/6/22/pubmed PY - 2000/7/25/medline PY - 2000/6/22/entrez SP - 1076 EP - 8 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 47 IS - 11 N2 - OBJECTIVE: Malaria is a resurging problem all over the country and rapid diagnosis is mandatory to decrease the morbidity and mortality and for control of malaria. In the current study the aim was to evaluate the usefulness of rapid Plasmodium falciparum antigen detection and to compare its utility over conventional peripheral thick and thin smear examination. METHODS: Three hundred fifty seven randomly selected patients with pyrexia and or atypical presentations of malaria, found initially negative for malaria were subjected to thick and thin smear examination and Plasmodium falciparum antigen detection test by using commercially available Parasight F. kit. RESULTS: 54.6% of cases presented with pyrexia, while other presentations of falciparum malaria were less frequently encountered (162/357). Eighty five patients (23.8%) were diagnosed as having falciparum malaria based on smear/Parasight F. Test. Eighty- four of these patients were positive for Parasight F. test and only 34.51% of these cases were also positive on smear examination. CONCLUSION: The antigen detection test for Plasmodium falciparum is useful for rapid diagnosis of Plasmodium falciparum malaria. It could detect 65.5% cases of falciparum malaria which were initially negative by peripheral smear examination. Hence, this technique is superior to peripheral smear staining and helps early diagnosis. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/10862317/Rapid_diagnosis_of_falciparum_malaria_by_detection_of_Plasmodium_falciparum_HRP_2_antigen_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -