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Neuroprotective antioxidants from marijuana.
Ann N Y Acad Sci. 2000; 899:274-82.AN

Abstract

Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.

Authors+Show Affiliations

Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892, USA. aidan@codon.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10863546

Citation

Hampson, A J., et al. "Neuroprotective Antioxidants From Marijuana." Annals of the New York Academy of Sciences, vol. 899, 2000, pp. 274-82.
Hampson AJ, Grimaldi M, Lolic M, et al. Neuroprotective antioxidants from marijuana. Ann N Y Acad Sci. 2000;899:274-82.
Hampson, A. J., Grimaldi, M., Lolic, M., Wink, D., Rosenthal, R., & Axelrod, J. (2000). Neuroprotective antioxidants from marijuana. Annals of the New York Academy of Sciences, 899, 274-82.
Hampson AJ, et al. Neuroprotective Antioxidants From Marijuana. Ann N Y Acad Sci. 2000;899:274-82. PubMed PMID: 10863546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective antioxidants from marijuana. AU - Hampson,A J, AU - Grimaldi,M, AU - Lolic,M, AU - Wink,D, AU - Rosenthal,R, AU - Axelrod,J, PY - 2000/6/23/pubmed PY - 2000/7/15/medline PY - 2000/6/23/entrez SP - 274 EP - 82 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 899 N2 - Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/10863546/Neuroprotective_antioxidants_from_marijuana_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2000&volume=899&spage=274 DB - PRIME DP - Unbound Medicine ER -