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[Relevant antibodies in dysimmune neuropathies].
Rev Neurol. 2000 Mar 16-31; 30(6):510-4.RN

Abstract

INTRODUCTION

In the last 15 years a number of autoantibodies against antigens of the peripheral nervous system have been associated, in some cases, to specific clinical features.

DEVELOPMENT

Antibodies to MAG or gangliosides have been described in neuropathies associated to monoclonal gammopathy or inflammatory polyneuropathies, such as Guillain-Barré syndrome or multifocal motor neuropathy. A lot of research is devoted to the characterization of known antibodies to glycolipids and the discovery of new ones. Furthermore, experimental models both with animals and in vitro preparations are performed in order to unravel the possible immunopathological role of these antibodies.

CONCLUSIONS

It is very important to define the clinical features of these patients precisely in order to establish consistent associations between: presence of antibodies to specific antigens of the peripheral nervous system and clinical syndromes. A deeper knowledge of the antigens and antibodies involved in these neuropathies may be very helpful in the follow-up of these patients and also for future therapies.

Authors+Show Affiliations

Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

10863722

Citation

Gallardo, E, et al. "[Relevant Antibodies in Dysimmune Neuropathies]." Revista De Neurologia, vol. 30, no. 6, 2000, pp. 510-4.
Gallardo E, Rojas R, Illa I. [Relevant antibodies in dysimmune neuropathies]. Rev Neurol. 2000;30(6):510-4.
Gallardo, E., Rojas, R., & Illa, I. (2000). [Relevant antibodies in dysimmune neuropathies]. Revista De Neurologia, 30(6), 510-4.
Gallardo E, Rojas R, Illa I. [Relevant Antibodies in Dysimmune Neuropathies]. Rev Neurol. 2000 Mar 16-31;30(6):510-4. PubMed PMID: 10863722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relevant antibodies in dysimmune neuropathies]. AU - Gallardo,E, AU - Rojas,R, AU - Illa,I, PY - 2000/6/23/pubmed PY - 2000/8/6/medline PY - 2000/6/23/entrez SP - 510 EP - 4 JF - Revista de neurologia JO - Rev Neurol VL - 30 IS - 6 N2 - INTRODUCTION: In the last 15 years a number of autoantibodies against antigens of the peripheral nervous system have been associated, in some cases, to specific clinical features. DEVELOPMENT: Antibodies to MAG or gangliosides have been described in neuropathies associated to monoclonal gammopathy or inflammatory polyneuropathies, such as Guillain-Barré syndrome or multifocal motor neuropathy. A lot of research is devoted to the characterization of known antibodies to glycolipids and the discovery of new ones. Furthermore, experimental models both with animals and in vitro preparations are performed in order to unravel the possible immunopathological role of these antibodies. CONCLUSIONS: It is very important to define the clinical features of these patients precisely in order to establish consistent associations between: presence of antibodies to specific antigens of the peripheral nervous system and clinical syndromes. A deeper knowledge of the antigens and antibodies involved in these neuropathies may be very helpful in the follow-up of these patients and also for future therapies. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/10863722/[Relevant_antibodies_in_dysimmune_neuropathies]_ DB - PRIME DP - Unbound Medicine ER -