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Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues.
Br J Cancer. 2000 Jun; 82(12):1946-51.BJ

Abstract

Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomere repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that reactivation of telomerase plays an important role in carcinogenesis. In this study, the status of telomerase activity in diseased human nasopharyngeal lesions was determined by the telomeric repeat amplification protocol (TRAP). Fifty-four patients participated including 17 inflammation or hyperplasia, eight with squamous metaplasia, and 29 with different stages of carcinomas. Telomerase activity was detected in 1 of 17 (5.9%) inflammatory or lymphoid hyperplastic tissues, 3 of 8 (37.5%) squamous metaplastic, and 25 of 29 (86.2%) carcinoma tissues. The differences in telomerase expression in these groups is statistically significant (P < 0.001). Levels of telomerase activity correlated with tumour stage (P = 0.024). These results suggest that telomerase reactivation plays a role in the carcinogenesis of nasopharyngeal cancer. Since telomerase activity is found in the majority of nasopharyngeal cancers and a subset of metaplasia, this enzyme may be served as a reference to monitoring the status of abnormal nasopharyngeal tissues.

Authors+Show Affiliations

Department of Radiation Oncology, Chang Guang Memorial Hospital, Taoyuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10864202

Citation

Chang, J T., et al. "Telomerase Activity Is Frequently Found in Metaplastic and Malignant Human Nasopharyngeal Tissues." British Journal of Cancer, vol. 82, no. 12, 2000, pp. 1946-51.
Chang JT, Liao CT, Jung SM, et al. Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues. Br J Cancer. 2000;82(12):1946-51.
Chang, J. T., Liao, C. T., Jung, S. M., Wang, T. C., See, L. C., & Cheng, A. J. (2000). Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues. British Journal of Cancer, 82(12), 1946-51.
Chang JT, et al. Telomerase Activity Is Frequently Found in Metaplastic and Malignant Human Nasopharyngeal Tissues. Br J Cancer. 2000;82(12):1946-51. PubMed PMID: 10864202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues. AU - Chang,J T, AU - Liao,C T, AU - Jung,S M, AU - Wang,T C, AU - See,L C, AU - Cheng,A J, PY - 2000/6/23/pubmed PY - 2000/7/15/medline PY - 2000/6/23/entrez SP - 1946 EP - 51 JF - British journal of cancer JO - Br J Cancer VL - 82 IS - 12 N2 - Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomere repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that reactivation of telomerase plays an important role in carcinogenesis. In this study, the status of telomerase activity in diseased human nasopharyngeal lesions was determined by the telomeric repeat amplification protocol (TRAP). Fifty-four patients participated including 17 inflammation or hyperplasia, eight with squamous metaplasia, and 29 with different stages of carcinomas. Telomerase activity was detected in 1 of 17 (5.9%) inflammatory or lymphoid hyperplastic tissues, 3 of 8 (37.5%) squamous metaplastic, and 25 of 29 (86.2%) carcinoma tissues. The differences in telomerase expression in these groups is statistically significant (P < 0.001). Levels of telomerase activity correlated with tumour stage (P = 0.024). These results suggest that telomerase reactivation plays a role in the carcinogenesis of nasopharyngeal cancer. Since telomerase activity is found in the majority of nasopharyngeal cancers and a subset of metaplasia, this enzyme may be served as a reference to monitoring the status of abnormal nasopharyngeal tissues. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/10864202/Telomerase_activity_is_frequently_found_in_metaplastic_and_malignant_human_nasopharyngeal_tissues_ L2 - https://doi.org/10.1054/bjoc.2000.1194 DB - PRIME DP - Unbound Medicine ER -