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Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency.
Clin Nutr. 2000 Apr; 19(2):137-9.CN

Abstract

We describe a case of methylmalonic aciduria (MMA) occurred in a 22-month-old boy whose diet was exclusively based upon breast-feeding from a mother following a long-lasting strict vegetarian diet. Clinical picture showed a dramatic onset, with a profound drowsiness associated with a severe metabolic acidosis, hyperammonemia, macrocytic anemia, ketonuria, and massive methylmalonic aciduria without homocystinuria. Both symptoms and biochemical findings quickly improved thanks to prompt vitamin B(12)parenteral therapy. Biochemical and enzymatic findings allowed a diagnosis of mild mutase deficiency, which only and inadequate dietary B(12)contribution might have revealed. Our case highlights the risk of a prolonged strictly vegetarian diet of lactating mother for providing inadequate amounts of some nutrients to the breast-fed baby. Moreover, such a dietary behaviour could dramatically unmask otherwise clinically unapparent metabolic defects in the baby.

Authors+Show Affiliations

Department of Pediatrics, University of Florence, Meyer Children Hospital, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10867733

Citation

Ciani, F, et al. "Prolonged Exclusive Breast-feeding From Vegan Mother Causing an Acute Onset of Isolated Methylmalonic Aciduria Due to a Mild Mutase Deficiency." Clinical Nutrition (Edinburgh, Scotland), vol. 19, no. 2, 2000, pp. 137-9.
Ciani F, Poggi GM, Pasquini E, et al. Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency. Clin Nutr. 2000;19(2):137-9.
Ciani, F., Poggi, G. M., Pasquini, E., Donati, M. A., & Zammarchi, E. (2000). Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency. Clinical Nutrition (Edinburgh, Scotland), 19(2), 137-9.
Ciani F, et al. Prolonged Exclusive Breast-feeding From Vegan Mother Causing an Acute Onset of Isolated Methylmalonic Aciduria Due to a Mild Mutase Deficiency. Clin Nutr. 2000;19(2):137-9. PubMed PMID: 10867733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency. AU - Ciani,F, AU - Poggi,G M, AU - Pasquini,E, AU - Donati,M A, AU - Zammarchi,E, PY - 2000/6/27/pubmed PY - 2000/8/1/medline PY - 2000/6/27/entrez SP - 137 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 19 IS - 2 N2 - We describe a case of methylmalonic aciduria (MMA) occurred in a 22-month-old boy whose diet was exclusively based upon breast-feeding from a mother following a long-lasting strict vegetarian diet. Clinical picture showed a dramatic onset, with a profound drowsiness associated with a severe metabolic acidosis, hyperammonemia, macrocytic anemia, ketonuria, and massive methylmalonic aciduria without homocystinuria. Both symptoms and biochemical findings quickly improved thanks to prompt vitamin B(12)parenteral therapy. Biochemical and enzymatic findings allowed a diagnosis of mild mutase deficiency, which only and inadequate dietary B(12)contribution might have revealed. Our case highlights the risk of a prolonged strictly vegetarian diet of lactating mother for providing inadequate amounts of some nutrients to the breast-fed baby. Moreover, such a dietary behaviour could dramatically unmask otherwise clinically unapparent metabolic defects in the baby. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/10867733/Prolonged_exclusive_breast_feeding_from_vegan_mother_causing_an_acute_onset_of_isolated_methylmalonic_aciduria_due_to_a_mild_mutase_deficiency_ DB - PRIME DP - Unbound Medicine ER -