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Early-life physical activity and postmenopausal breast cancer: effect of body size and weight change.

Abstract

It is not yet known whether early-life physical activity reduces the risk of developing breast cancer. Subgroup analyses according to menopausal status and body mass may help clarify this association. Data from a population-based case-control study of female residents of Wisconsin, Massachusetts, Maine, and New Hampshire were used to examine associations between body mass and breast cancer risk. Cases (n = 4614) were identified by each state's tumor registry; controls (n = 5817) were randomly selected from population lists. Frequency of participation in strenuous physical activity when 14-22 years of age, weight at age 18 and 5 years before interview, height, and other factors were ascertained through structured telephone interviews. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using logistic regression. Reductions in postmenopausal breast cancer risk associated with strenuous physical activity were greatest for women in the fourth quartile of body mass index at age 18; the OR for women with the highest activity frequency on average (> or =once/day) was 0.45 (95% CI = 0.26-0.79). Associations with frequency of activity also varied by weight change. Compared to women with no activity and little adult weight gain, frequent physical activity was associated with reduced postmenopausal breast cancer risk in women who had lost weight since age 18 (OR = 0.19, 95% CI = 0.05-0.70) or had gained little or modest amounts of weight (weight gain: first tertile, OR = 0.36, 95% CI = 0.05-0.85; second tertile, OR = 0.31, 95% CI = 0.14-0.66). Weighted MET score analyses yielded similar but less inverse results. These findings suggest that the reduced risk of postmenopausal breast cancer associated with frequent, early-life physical activity may be greatest in women who, over the adult years, either lost weight or gained only modest amounts.

Authors+Show Affiliations

University of Wisconsin Comprehensive Cancer Center, Madison 53706, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10868694

Citation

Shoff, S M., et al. "Early-life Physical Activity and Postmenopausal Breast Cancer: Effect of Body Size and Weight Change." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 9, no. 6, 2000, pp. 591-5.
Shoff SM, Newcomb PA, Trentham-Dietz A, et al. Early-life physical activity and postmenopausal breast cancer: effect of body size and weight change. Cancer Epidemiol Biomarkers Prev. 2000;9(6):591-5.
Shoff, S. M., Newcomb, P. A., Trentham-Dietz, A., Remington, P. L., Mittendorf, R., Greenberg, E. R., & Willett, W. C. (2000). Early-life physical activity and postmenopausal breast cancer: effect of body size and weight change. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 9(6), pp. 591-5.
Shoff SM, et al. Early-life Physical Activity and Postmenopausal Breast Cancer: Effect of Body Size and Weight Change. Cancer Epidemiol Biomarkers Prev. 2000;9(6):591-5. PubMed PMID: 10868694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early-life physical activity and postmenopausal breast cancer: effect of body size and weight change. AU - Shoff,S M, AU - Newcomb,P A, AU - Trentham-Dietz,A, AU - Remington,P L, AU - Mittendorf,R, AU - Greenberg,E R, AU - Willett,W C, PY - 2000/6/27/pubmed PY - 2001/2/28/medline PY - 2000/6/27/entrez SP - 591 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 9 IS - 6 N2 - It is not yet known whether early-life physical activity reduces the risk of developing breast cancer. Subgroup analyses according to menopausal status and body mass may help clarify this association. Data from a population-based case-control study of female residents of Wisconsin, Massachusetts, Maine, and New Hampshire were used to examine associations between body mass and breast cancer risk. Cases (n = 4614) were identified by each state's tumor registry; controls (n = 5817) were randomly selected from population lists. Frequency of participation in strenuous physical activity when 14-22 years of age, weight at age 18 and 5 years before interview, height, and other factors were ascertained through structured telephone interviews. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using logistic regression. Reductions in postmenopausal breast cancer risk associated with strenuous physical activity were greatest for women in the fourth quartile of body mass index at age 18; the OR for women with the highest activity frequency on average (> or =once/day) was 0.45 (95% CI = 0.26-0.79). Associations with frequency of activity also varied by weight change. Compared to women with no activity and little adult weight gain, frequent physical activity was associated with reduced postmenopausal breast cancer risk in women who had lost weight since age 18 (OR = 0.19, 95% CI = 0.05-0.70) or had gained little or modest amounts of weight (weight gain: first tertile, OR = 0.36, 95% CI = 0.05-0.85; second tertile, OR = 0.31, 95% CI = 0.14-0.66). Weighted MET score analyses yielded similar but less inverse results. These findings suggest that the reduced risk of postmenopausal breast cancer associated with frequent, early-life physical activity may be greatest in women who, over the adult years, either lost weight or gained only modest amounts. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/10868694/Early_life_physical_activity_and_postmenopausal_breast_cancer:_effect_of_body_size_and_weight_change_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10868694 DB - PRIME DP - Unbound Medicine ER -