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Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics.
Alcohol Alcohol 2000 May-Jun; 35(3):242-8AA

Abstract

Drinking, but not alcohol-dependent, 18-29-year-old daughters of alcoholics (n = 38) from the Collaborative Study on the Genetics of Alcoholism were compared to 75 family-history-positive (FHP) men from the same families, and 68 family-history-negative (FHN) male controls. Subjects received 0.75 ml/kg of ethanol (for women), 0.9 ml/kg of ethanol (for men), and placebo, each of which was consumed over 8 min on different occasions. The breath-alcohol concentrations (BrAC) and reactions to alcohol [using the Subjective High Assessment Scale (SHAS) and body sway measures] were evaluated over 210 min. The results indicate that, despite slightly higher BrAC values for the FHP men, on the SHAS the FHP women and the FHP men demonstrated significantly lower scores than the FHN male controls, although the values for FHP men and women did not differ. On body sway, the FHP men showed evidence of less alcohol-related increases than FHN men, and there was a trend in the same direction for FHP women, but only early in the session (e.g. at 60 min). Pilot data for 11 FHN women revealed higher scores for both SHAS and body sway at 60 min, compared to FHP women, but, perhaps reflecting the small number of subjects, the family history differences were not significant. Overall, the results in FHP women resemble those for FHP men, and suggest that a low level of response to alcohol might also be a characteristic of daughters of alcoholics.

Authors+Show Affiliations

Department of Psychiatry, Veterans Affairs San Diego Healthcare System, CA 92161-2002, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10869242

Citation

Schuckit, M A., et al. "Response to Alcohol in Daughters of Alcoholics: a Pilot Study and a Comparison With Sons of Alcoholics." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 35, no. 3, 2000, pp. 242-8.
Schuckit MA, Smith TL, Kalmijn J, et al. Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol. 2000;35(3):242-8.
Schuckit, M. A., Smith, T. L., Kalmijn, J., Tsuang, J., Hesselbrock, V., & Bucholz, K. (2000). Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol and Alcoholism (Oxford, Oxfordshire), 35(3), pp. 242-8.
Schuckit MA, et al. Response to Alcohol in Daughters of Alcoholics: a Pilot Study and a Comparison With Sons of Alcoholics. Alcohol Alcohol. 2000;35(3):242-8. PubMed PMID: 10869242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. AU - Schuckit,M A, AU - Smith,T L, AU - Kalmijn,J, AU - Tsuang,J, AU - Hesselbrock,V, AU - Bucholz,K, PY - 2000/6/28/pubmed PY - 2000/9/2/medline PY - 2000/6/28/entrez SP - 242 EP - 8 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol. VL - 35 IS - 3 N2 - Drinking, but not alcohol-dependent, 18-29-year-old daughters of alcoholics (n = 38) from the Collaborative Study on the Genetics of Alcoholism were compared to 75 family-history-positive (FHP) men from the same families, and 68 family-history-negative (FHN) male controls. Subjects received 0.75 ml/kg of ethanol (for women), 0.9 ml/kg of ethanol (for men), and placebo, each of which was consumed over 8 min on different occasions. The breath-alcohol concentrations (BrAC) and reactions to alcohol [using the Subjective High Assessment Scale (SHAS) and body sway measures] were evaluated over 210 min. The results indicate that, despite slightly higher BrAC values for the FHP men, on the SHAS the FHP women and the FHP men demonstrated significantly lower scores than the FHN male controls, although the values for FHP men and women did not differ. On body sway, the FHP men showed evidence of less alcohol-related increases than FHN men, and there was a trend in the same direction for FHP women, but only early in the session (e.g. at 60 min). Pilot data for 11 FHN women revealed higher scores for both SHAS and body sway at 60 min, compared to FHP women, but, perhaps reflecting the small number of subjects, the family history differences were not significant. Overall, the results in FHP women resemble those for FHP men, and suggest that a low level of response to alcohol might also be a characteristic of daughters of alcoholics. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/10869242/Response_to_alcohol_in_daughters_of_alcoholics:_a_pilot_study_and_a_comparison_with_sons_of_alcoholics_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/35.3.242 DB - PRIME DP - Unbound Medicine ER -