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Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men.
Am J Clin Nutr. 2000 Jul; 72(1):36-41.AJ

Abstract

BACKGROUND

Cholesterol ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to apolipoprotein (apo) B-containing lipoproteins. The possible atherogenic role of this protein is controversial. Diet may influence plasma CETP concentrations.

OBJECTIVE

The objective was to determine whether the changes in plasma lipids observed after consumption of 2 lipid-lowering diets are associated with changes in plasma CETP concentrations.

DESIGN

: We studied 41 healthy, normolipidemic men over 3 consecutive 4-wk dietary periods: a saturated fatty acid-rich diet (SFA diet: 38% fat, 20% saturated fat), a National Cholesterol Education Program Step I diet (NCEP Step I diet: 28% fat, 10% saturated fat), and a monounsaturated fatty acid-rich diet (MUFA diet: 38% fat, 22% monounsaturated fat). Cholesterol content (27.5 mg/MJ) was kept constant during the 3 periods. Plasma concentrations of total, LDL, and HDL cholesterol; triacylglycerol; apo A-I and B; and CETP were measured at the end of each dietary period.

RESULTS

Compared with the SFA diet, both lipid-lowering diets significantly decreased plasma total and LDL cholesterol, apo B, and CETP. Only the NCEP Step I diet lowered plasma HDL cholesterol. Positive, significant correlations were found between plasma CETP and total (r = 0.3868, P < 0.0001) and LDL (r = 0.4454, P < 0.0001) cholesterol and also between changes in CETP concentrations and those of total (r = 0.4543, P < 0.0001) and LDL (r = 0.4554, P < 0.0001) cholesterol.

CONCLUSIONS

The isoenergetic substitution of a high-saturated fatty acid diet with an NCEP Step I or a high-monounsaturated fatty acid diet decreases plasma CETP concentrations.

Authors+Show Affiliations

Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía, Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10871558

Citation

Jansen, S, et al. "Low-fat and High-monounsaturated Fatty Acid Diets Decrease Plasma Cholesterol Ester Transfer Protein Concentrations in Young, Healthy, Normolipemic Men." The American Journal of Clinical Nutrition, vol. 72, no. 1, 2000, pp. 36-41.
Jansen S, López-Miranda J, Castro P, et al. Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. Am J Clin Nutr. 2000;72(1):36-41.
Jansen, S., López-Miranda, J., Castro, P., López-Segura, F., Marín, C., Ordovás, J. M., Paz, E., Jiménez-Perepérez, J., Fuentes, F., & Pérez-Jiménez, F. (2000). Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. The American Journal of Clinical Nutrition, 72(1), 36-41.
Jansen S, et al. Low-fat and High-monounsaturated Fatty Acid Diets Decrease Plasma Cholesterol Ester Transfer Protein Concentrations in Young, Healthy, Normolipemic Men. Am J Clin Nutr. 2000;72(1):36-41. PubMed PMID: 10871558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. AU - Jansen,S, AU - López-Miranda,J, AU - Castro,P, AU - López-Segura,F, AU - Marín,C, AU - Ordovás,J M, AU - Paz,E, AU - Jiménez-Perepérez,J, AU - Fuentes,F, AU - Pérez-Jiménez,F, PY - 2000/6/29/pubmed PY - 2000/9/9/medline PY - 2000/6/29/entrez SP - 36 EP - 41 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 72 IS - 1 N2 - BACKGROUND: Cholesterol ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to apolipoprotein (apo) B-containing lipoproteins. The possible atherogenic role of this protein is controversial. Diet may influence plasma CETP concentrations. OBJECTIVE: The objective was to determine whether the changes in plasma lipids observed after consumption of 2 lipid-lowering diets are associated with changes in plasma CETP concentrations. DESIGN: : We studied 41 healthy, normolipidemic men over 3 consecutive 4-wk dietary periods: a saturated fatty acid-rich diet (SFA diet: 38% fat, 20% saturated fat), a National Cholesterol Education Program Step I diet (NCEP Step I diet: 28% fat, 10% saturated fat), and a monounsaturated fatty acid-rich diet (MUFA diet: 38% fat, 22% monounsaturated fat). Cholesterol content (27.5 mg/MJ) was kept constant during the 3 periods. Plasma concentrations of total, LDL, and HDL cholesterol; triacylglycerol; apo A-I and B; and CETP were measured at the end of each dietary period. RESULTS: Compared with the SFA diet, both lipid-lowering diets significantly decreased plasma total and LDL cholesterol, apo B, and CETP. Only the NCEP Step I diet lowered plasma HDL cholesterol. Positive, significant correlations were found between plasma CETP and total (r = 0.3868, P < 0.0001) and LDL (r = 0.4454, P < 0.0001) cholesterol and also between changes in CETP concentrations and those of total (r = 0.4543, P < 0.0001) and LDL (r = 0.4554, P < 0.0001) cholesterol. CONCLUSIONS: The isoenergetic substitution of a high-saturated fatty acid diet with an NCEP Step I or a high-monounsaturated fatty acid diet decreases plasma CETP concentrations. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10871558/Low_fat_and_high_monounsaturated_fatty_acid_diets_decrease_plasma_cholesterol_ester_transfer_protein_concentrations_in_young_healthy_normolipemic_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/72.1.36 DB - PRIME DP - Unbound Medicine ER -