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Insulin resistance and hypertension. Patients in double jeopardy for cardiovascular disease.
Geriatrics 2000; 55(6):28-32, 35G

Abstract

Essential hypertension is prevalent among older individuals, and approximately 50% of persons with hypertension can be considered to have insulin resistance and hyperinsulinemia. It appears likely that insulin resistance and hyperinsulinemia predispose to, rather than result from, hypertension. Insulin resistance is associated with abnormalities in lipoprotein metabolism, hypercoagulability, and endothelial function, which probably account in part for the increased cardiovascular risk among hypertensive patients. To identify this subset of patients, all hypertensive patients should be screened for diabetes and lipid abnormalities. The presence of impaired glucose tolerance, diabetes, or hypertriglyceridemia and low HDL suggest the presence of insulin resistance. Insulin resistant patients, in particular, will benefit from exercise and weight loss.

Authors+Show Affiliations

Department of Medicine, Stanford University School of Medicine, CA, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10872343

Citation

McLaughlin, T, and G Reaven. "Insulin Resistance and Hypertension. Patients in Double Jeopardy for Cardiovascular Disease." Geriatrics, vol. 55, no. 6, 2000, pp. 28-32, 35.
McLaughlin T, Reaven G. Insulin resistance and hypertension. Patients in double jeopardy for cardiovascular disease. Geriatrics. 2000;55(6):28-32, 35.
McLaughlin, T., & Reaven, G. (2000). Insulin resistance and hypertension. Patients in double jeopardy for cardiovascular disease. Geriatrics, 55(6), pp. 28-32, 35.
McLaughlin T, Reaven G. Insulin Resistance and Hypertension. Patients in Double Jeopardy for Cardiovascular Disease. Geriatrics. 2000;55(6):28-32, 35. PubMed PMID: 10872343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and hypertension. Patients in double jeopardy for cardiovascular disease. AU - McLaughlin,T, AU - Reaven,G, PY - 2000/6/29/pubmed PY - 2000/7/15/medline PY - 2000/6/29/entrez SP - 28-32, 35 JF - Geriatrics JO - Geriatrics VL - 55 IS - 6 N2 - Essential hypertension is prevalent among older individuals, and approximately 50% of persons with hypertension can be considered to have insulin resistance and hyperinsulinemia. It appears likely that insulin resistance and hyperinsulinemia predispose to, rather than result from, hypertension. Insulin resistance is associated with abnormalities in lipoprotein metabolism, hypercoagulability, and endothelial function, which probably account in part for the increased cardiovascular risk among hypertensive patients. To identify this subset of patients, all hypertensive patients should be screened for diabetes and lipid abnormalities. The presence of impaired glucose tolerance, diabetes, or hypertriglyceridemia and low HDL suggest the presence of insulin resistance. Insulin resistant patients, in particular, will benefit from exercise and weight loss. SN - 0016-867X UR - https://www.unboundmedicine.com/medline/citation/10872343/Insulin_resistance_and_hypertension__Patients_in_double_jeopardy_for_cardiovascular_disease_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -