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Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Defense hospitalization data.
Am J Epidemiol. 2000 Jun 01; 151(11):1053-9.AJ

Abstract

Since the Persian Gulf War ended in 1991, veterans have reported diverse, unexplained symptoms. Some have wondered if their development of systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia might be related to Gulf War service. The authors used Cox proportional hazard modeling to determine whether regular, active-duty service personnel deployed to the Persian Gulf War (n = 551,841) were at increased risk of postwar hospitalization with the three conditions compared with nondeployed Gulf War era service personnel (n = 1,478,704). All hospitalizations in Department of Defense facilities from October 1, 1988, through July 31, 1997, were examined. With removal of personnel diagnosed with any of the three diseases before August 1, 1991, and adjustment for multiple covariates, Gulf War veterans were not at increased risk of postwar hospitalization due to systemic lupus erythematosus (risk ratio (RR) = 0.94, 95% confidence interval (CI): 0.65, 1.35). Because of the small number of cases and wide confidence limits, the data regarding amyotrophic lateral sclerosis were inconclusive. Gulf War veterans were slightly at risk of postwar hospitalization for fibromyalgia (RR = 1.23, 95% Cl: 1.05, 1.43); however, this risk difference was probably due to the Gulf War veteran clinical evaluation program beginning in 1994. These data do not support Gulf War service and disease associations.

Authors+Show Affiliations

Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, CA 92186-5122, USA. smith@nhrc.navy.milNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10873128

Citation

Smith, T C., et al. "Is Systemic Lupus Erythematosus, Amyotrophic Lateral Sclerosis, or Fibromyalgia Associated With Persian Gulf War Service? an Examination of Department of Defense Hospitalization Data." American Journal of Epidemiology, vol. 151, no. 11, 2000, pp. 1053-9.
Smith TC, Gray GC, Knoke JD. Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Defense hospitalization data. Am J Epidemiol. 2000;151(11):1053-9.
Smith, T. C., Gray, G. C., & Knoke, J. D. (2000). Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Defense hospitalization data. American Journal of Epidemiology, 151(11), 1053-9.
Smith TC, Gray GC, Knoke JD. Is Systemic Lupus Erythematosus, Amyotrophic Lateral Sclerosis, or Fibromyalgia Associated With Persian Gulf War Service? an Examination of Department of Defense Hospitalization Data. Am J Epidemiol. 2000 Jun 1;151(11):1053-9. PubMed PMID: 10873128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Defense hospitalization data. AU - Smith,T C, AU - Gray,G C, AU - Knoke,J D, PY - 2000/6/29/pubmed PY - 2000/7/15/medline PY - 2000/6/29/entrez SP - 1053 EP - 9 JF - American journal of epidemiology JO - Am J Epidemiol VL - 151 IS - 11 N2 - Since the Persian Gulf War ended in 1991, veterans have reported diverse, unexplained symptoms. Some have wondered if their development of systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia might be related to Gulf War service. The authors used Cox proportional hazard modeling to determine whether regular, active-duty service personnel deployed to the Persian Gulf War (n = 551,841) were at increased risk of postwar hospitalization with the three conditions compared with nondeployed Gulf War era service personnel (n = 1,478,704). All hospitalizations in Department of Defense facilities from October 1, 1988, through July 31, 1997, were examined. With removal of personnel diagnosed with any of the three diseases before August 1, 1991, and adjustment for multiple covariates, Gulf War veterans were not at increased risk of postwar hospitalization due to systemic lupus erythematosus (risk ratio (RR) = 0.94, 95% confidence interval (CI): 0.65, 1.35). Because of the small number of cases and wide confidence limits, the data regarding amyotrophic lateral sclerosis were inconclusive. Gulf War veterans were slightly at risk of postwar hospitalization for fibromyalgia (RR = 1.23, 95% Cl: 1.05, 1.43); however, this risk difference was probably due to the Gulf War veteran clinical evaluation program beginning in 1994. These data do not support Gulf War service and disease associations. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/10873128/Is_systemic_lupus_erythematosus_amyotrophic_lateral_sclerosis_or_fibromyalgia_associated_with_Persian_Gulf_War_service_An_examination_of_Department_of_Defense_hospitalization_data_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a010147 DB - PRIME DP - Unbound Medicine ER -