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Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation.
Biochem Biophys Res Commun. 2000 Jun 24; 273(1):117-22.BB

Abstract

CD137 (ILA/4-1BB), a member of the TNF receptor family, regulates activation, survival and proliferation of primary human monocytes. Here we compare the activities of lipopolysaccharide (LPS), a classical and potent monocyte activator to that of CD137. LPS is a more potent activator of monocytes, as evidenced by a stronger induction of the proinflammatory cytokine IL-8. However, CD137 could further increase maximal cytokine induction by LPS, which points to separate signaling pathways for LPS and CD137. Also, expression of myc was only induced by the combination of CD137 and LPS. Expression of macrophage colony-stimulating factor is induced more potently by CD137, but an additive effect is obtained by the combination of CD137 and LPS. Monocyte/macrophage survival and proliferation is only induced by CD137. LPS counteracts both activities of CD137 via activation induced cell death. While LPS has a role in activation of monocytes in innate immunity, the CD137 receptor/ligand system seems to deliver an activating signal to monocyte in acquired immunity.

Authors+Show Affiliations

Department of Pathology, University of Regensburg, Regensburg, 93042, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10873573

Citation

Langstein, J, et al. "Comparative Analysis of CD137 and LPS Effects On Monocyte Activation, Survival, and Proliferation." Biochemical and Biophysical Research Communications, vol. 273, no. 1, 2000, pp. 117-22.
Langstein J, Becke FM, Söllner L, et al. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000;273(1):117-22.
Langstein, J., Becke, F. M., Söllner, L., Krause, G., Brockhoff, G., Kreutz, M., Andreesen, R., & Schwarz, H. (2000). Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochemical and Biophysical Research Communications, 273(1), 117-22.
Langstein J, et al. Comparative Analysis of CD137 and LPS Effects On Monocyte Activation, Survival, and Proliferation. Biochem Biophys Res Commun. 2000 Jun 24;273(1):117-22. PubMed PMID: 10873573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. AU - Langstein,J, AU - Becke,F M, AU - Söllner,L, AU - Krause,G, AU - Brockhoff,G, AU - Kreutz,M, AU - Andreesen,R, AU - Schwarz,H, PY - 2000/6/30/pubmed PY - 2000/6/30/medline PY - 2000/6/30/entrez SP - 117 EP - 22 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 273 IS - 1 N2 - CD137 (ILA/4-1BB), a member of the TNF receptor family, regulates activation, survival and proliferation of primary human monocytes. Here we compare the activities of lipopolysaccharide (LPS), a classical and potent monocyte activator to that of CD137. LPS is a more potent activator of monocytes, as evidenced by a stronger induction of the proinflammatory cytokine IL-8. However, CD137 could further increase maximal cytokine induction by LPS, which points to separate signaling pathways for LPS and CD137. Also, expression of myc was only induced by the combination of CD137 and LPS. Expression of macrophage colony-stimulating factor is induced more potently by CD137, but an additive effect is obtained by the combination of CD137 and LPS. Monocyte/macrophage survival and proliferation is only induced by CD137. LPS counteracts both activities of CD137 via activation induced cell death. While LPS has a role in activation of monocytes in innate immunity, the CD137 receptor/ligand system seems to deliver an activating signal to monocyte in acquired immunity. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/10873573/Comparative_analysis_of_CD137_and_LPS_effects_on_monocyte_activation_survival_and_proliferation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(00)92889-4 DB - PRIME DP - Unbound Medicine ER -