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Biclonal chronic lymphocytic leukemia.
Am J Clin Pathol. 2000 Jun; 113(6):798-804.AJ

Abstract

Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+, CD23+ B-cell population seen in CLL; however, immunoglobulin light chain restriction by flow cytometry was not apparent as B cells expressed kappa or lambda light chains without a clear monotypic population. Molecular genetic analysis of flow cytometry-sorted cells (kappa and lambda populations) revealed in both cases 2 monoclonal B-cell populations. The characterization of these cases and a review of the issues surrounding biclonal CLL are presented.

Authors+Show Affiliations

Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10874880

Citation

Hsi, E D., et al. "Biclonal Chronic Lymphocytic Leukemia." American Journal of Clinical Pathology, vol. 113, no. 6, 2000, pp. 798-804.
Hsi ED, Hoeltge G, Tubbs RR. Biclonal chronic lymphocytic leukemia. Am J Clin Pathol. 2000;113(6):798-804.
Hsi, E. D., Hoeltge, G., & Tubbs, R. R. (2000). Biclonal chronic lymphocytic leukemia. American Journal of Clinical Pathology, 113(6), 798-804.
Hsi ED, Hoeltge G, Tubbs RR. Biclonal Chronic Lymphocytic Leukemia. Am J Clin Pathol. 2000;113(6):798-804. PubMed PMID: 10874880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biclonal chronic lymphocytic leukemia. AU - Hsi,E D, AU - Hoeltge,G, AU - Tubbs,R R, PY - 2000/6/30/pubmed PY - 2000/7/15/medline PY - 2000/6/30/entrez SP - 798 EP - 804 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 113 IS - 6 N2 - Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+, CD23+ B-cell population seen in CLL; however, immunoglobulin light chain restriction by flow cytometry was not apparent as B cells expressed kappa or lambda light chains without a clear monotypic population. Molecular genetic analysis of flow cytometry-sorted cells (kappa and lambda populations) revealed in both cases 2 monoclonal B-cell populations. The characterization of these cases and a review of the issues surrounding biclonal CLL are presented. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/10874880/Biclonal_chronic_lymphocytic_leukemia_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/V8AN-A2XP-7TDV-HR0T DB - PRIME DP - Unbound Medicine ER -