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The role of metals in neurodegenerative diseases.
Cell Mol Biol (Noisy-le-grand). 2000 Jun; 46(4):731-41.CM

Abstract

There is increasing evidence in a number of neurodegenerative diseases that transition metal-mediated abnormalities play a crucial role in disease pathogenesis. In this treatise, we review the role of metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases. In fact, while there is documented evidence for alterations in transition metal homeostasis, redox-activity and localization, it is also important to realize that alterations in specific copper- and iron-containing metalloenzymes also appear to play a crucial role in the neurodegenerative process.

Authors+Show Affiliations

Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10875436

Citation

Sayre, L M., et al. "The Role of Metals in Neurodegenerative Diseases." Cellular and Molecular Biology (Noisy-le-Grand, France), vol. 46, no. 4, 2000, pp. 731-41.
Sayre LM, Perry G, Atwood CS, et al. The role of metals in neurodegenerative diseases. Cell Mol Biol (Noisy-le-grand). 2000;46(4):731-41.
Sayre, L. M., Perry, G., Atwood, C. S., & Smith, M. A. (2000). The role of metals in neurodegenerative diseases. Cellular and Molecular Biology (Noisy-le-Grand, France), 46(4), 731-41.
Sayre LM, et al. The Role of Metals in Neurodegenerative Diseases. Cell Mol Biol (Noisy-le-grand). 2000;46(4):731-41. PubMed PMID: 10875436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of metals in neurodegenerative diseases. AU - Sayre,L M, AU - Perry,G, AU - Atwood,C S, AU - Smith,M A, PY - 2000/6/30/pubmed PY - 2001/2/28/medline PY - 2000/6/30/entrez SP - 731 EP - 41 JF - Cellular and molecular biology (Noisy-le-Grand, France) JO - Cell. Mol. Biol. (Noisy-le-grand) VL - 46 IS - 4 N2 - There is increasing evidence in a number of neurodegenerative diseases that transition metal-mediated abnormalities play a crucial role in disease pathogenesis. In this treatise, we review the role of metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases. In fact, while there is documented evidence for alterations in transition metal homeostasis, redox-activity and localization, it is also important to realize that alterations in specific copper- and iron-containing metalloenzymes also appear to play a crucial role in the neurodegenerative process. SN - 0145-5680 UR - https://www.unboundmedicine.com/medline/citation/10875436/The_role_of_metals_in_neurodegenerative_diseases_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -