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Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism.
Metabolism. 2000 Jun; 49(6):724-30.M

Abstract

Leptin levels have been shown previously to be associated with anthropometric parameters such as the body mass index (BMI), total body fat, and subcutaneous fat. Since apolipoprotein E (apoE) polymorphism is known to be a genetic marker affecting the relationship between certain anthropometric and metabolic parameters, we evaluated whether the leptin level and/or associations between the leptin level and body composition in non-insulin-dependent diabetic patients could be determined by apoE polymorphism. In 171 type 2 diabetic patients (105 male and 66 female), body composition (BMI, waist to hip ratio [WHR], fat mass, and visceral fat) was measured and fasting blood samples were obtained to determine the apoE genotype, leptin, glucose, and insulin levels, and the lipid profile. The mean leptin level for the whole group was 11.7 +/- 9.3 ng/mL, with a significant difference (P < .001) between men (7.1 +/- 4.9 ng/mL) and women (19.0 +/- 10.1 ng/mL). No difference was found for leptin levels or anthropometric variables between the 3 different apoE genotypes (E3/E3 homozygotes, E2 carriers, and E4 carriers). Only low-density lipoprotein (LDL) cholesterol was significantly different between the 3 apoE subgroups. The correlations of leptin with anthropometric variables, especially visceral fat, tended to be different between the 3 apoE groups, but this was not independent and no effect was found after controlling for the other parameters in the model. A multiple regression model containing gender, subcutaneous fat, fasting glucose, triglycerides, and high-density lipoprotein (HDL) cholesterol explained 81% of the variance in leptin levels. We conclude that apoE polymorphism has no effect on the leptin level or its associations with other anthropometric and metabolic parameters.

Authors+Show Affiliations

Department of Endocrinology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10877196

Citation

Wauters, M, et al. "Associations of Leptin With Body Fat Distribution and Metabolic Parameters in Non-insulin-dependent Diabetic Patients: No Effect of Apolipoprotein E Polymorphism." Metabolism: Clinical and Experimental, vol. 49, no. 6, 2000, pp. 724-30.
Wauters M, Considine R, Löfgren A, et al. Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism. Metabolism. 2000;49(6):724-30.
Wauters, M., Considine, R., Löfgren, A., Van Broeckhoven, C., Van der Auwera, J. C., De Leeuw, I., & Van Gaal, L. (2000). Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism. Metabolism: Clinical and Experimental, 49(6), 724-30.
Wauters M, et al. Associations of Leptin With Body Fat Distribution and Metabolic Parameters in Non-insulin-dependent Diabetic Patients: No Effect of Apolipoprotein E Polymorphism. Metabolism. 2000;49(6):724-30. PubMed PMID: 10877196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism. AU - Wauters,M, AU - Considine,R, AU - Löfgren,A, AU - Van Broeckhoven,C, AU - Van der Auwera,J C, AU - De Leeuw,I, AU - Van Gaal,L, PY - 2000/7/6/pubmed PY - 2000/7/25/medline PY - 2000/7/6/entrez SP - 724 EP - 30 JF - Metabolism: clinical and experimental JO - Metabolism VL - 49 IS - 6 N2 - Leptin levels have been shown previously to be associated with anthropometric parameters such as the body mass index (BMI), total body fat, and subcutaneous fat. Since apolipoprotein E (apoE) polymorphism is known to be a genetic marker affecting the relationship between certain anthropometric and metabolic parameters, we evaluated whether the leptin level and/or associations between the leptin level and body composition in non-insulin-dependent diabetic patients could be determined by apoE polymorphism. In 171 type 2 diabetic patients (105 male and 66 female), body composition (BMI, waist to hip ratio [WHR], fat mass, and visceral fat) was measured and fasting blood samples were obtained to determine the apoE genotype, leptin, glucose, and insulin levels, and the lipid profile. The mean leptin level for the whole group was 11.7 +/- 9.3 ng/mL, with a significant difference (P < .001) between men (7.1 +/- 4.9 ng/mL) and women (19.0 +/- 10.1 ng/mL). No difference was found for leptin levels or anthropometric variables between the 3 different apoE genotypes (E3/E3 homozygotes, E2 carriers, and E4 carriers). Only low-density lipoprotein (LDL) cholesterol was significantly different between the 3 apoE subgroups. The correlations of leptin with anthropometric variables, especially visceral fat, tended to be different between the 3 apoE groups, but this was not independent and no effect was found after controlling for the other parameters in the model. A multiple regression model containing gender, subcutaneous fat, fasting glucose, triglycerides, and high-density lipoprotein (HDL) cholesterol explained 81% of the variance in leptin levels. We conclude that apoE polymorphism has no effect on the leptin level or its associations with other anthropometric and metabolic parameters. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/10877196/Associations_of_leptin_with_body_fat_distribution_and_metabolic_parameters_in_non_insulin_dependent_diabetic_patients:_no_effect_of_apolipoprotein_E_polymorphism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(00)80056-6 DB - PRIME DP - Unbound Medicine ER -