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Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders.
Chem Phys Lipids 2000; 106(1):1-29CP

Abstract

Neural membranes contain several classes of glycerophospholipids which turnover at different rates with respect to their structure and localization in different cells and membranes. The glycerophospholipid composition of neural membranes greatly alters their functional efficacy. The length of glycerophospholipid acyl chain and the degree of saturation are important determinants of many membrane characteristics including the formation of lateral domains that are rich in polyunsaturated fatty acids. Receptor-mediated degradation of glycerophospholipids by phospholipases A(l), A(2), C, and D results in generation of second messengers such as arachidonic acid, eicosanoids, platelet activating factor and diacylglycerol. Thus, neural membrane phospholipids are a reservoir for second messengers. They are also involved in apoptosis, modulation of activities of transporters, and membrane-bound enzymes. Marked alterations in neural membrane glycerophospholipid composition have been reported to occur in neurological disorders. These alterations result in changes in membrane fluidity and permeability. These processes along with the accumulation of lipid peroxides and compromised energy metabolism may be responsible for the neurodegeneration observed in neurological disorders.

Authors+Show Affiliations

Department of Molecular and Cellular Biochemistry, Ohio State University, 1645 Neil Avenue, 465 Hamilton Hall, 43210, Columbus, OH, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10878232

Citation

Farooqui, A A., et al. "Glycerophospholipids in Brain: Their Metabolism, Incorporation Into Membranes, Functions, and Involvement in Neurological Disorders." Chemistry and Physics of Lipids, vol. 106, no. 1, 2000, pp. 1-29.
Farooqui AA, Horrocks LA, Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem Phys Lipids. 2000;106(1):1-29.
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2000). Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chemistry and Physics of Lipids, 106(1), pp. 1-29.
Farooqui AA, Horrocks LA, Farooqui T. Glycerophospholipids in Brain: Their Metabolism, Incorporation Into Membranes, Functions, and Involvement in Neurological Disorders. Chem Phys Lipids. 2000;106(1):1-29. PubMed PMID: 10878232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. AU - Farooqui,A A, AU - Horrocks,L A, AU - Farooqui,T, PY - 2000/7/6/pubmed PY - 2000/9/2/medline PY - 2000/7/6/entrez SP - 1 EP - 29 JF - Chemistry and physics of lipids JO - Chem. Phys. Lipids VL - 106 IS - 1 N2 - Neural membranes contain several classes of glycerophospholipids which turnover at different rates with respect to their structure and localization in different cells and membranes. The glycerophospholipid composition of neural membranes greatly alters their functional efficacy. The length of glycerophospholipid acyl chain and the degree of saturation are important determinants of many membrane characteristics including the formation of lateral domains that are rich in polyunsaturated fatty acids. Receptor-mediated degradation of glycerophospholipids by phospholipases A(l), A(2), C, and D results in generation of second messengers such as arachidonic acid, eicosanoids, platelet activating factor and diacylglycerol. Thus, neural membrane phospholipids are a reservoir for second messengers. They are also involved in apoptosis, modulation of activities of transporters, and membrane-bound enzymes. Marked alterations in neural membrane glycerophospholipid composition have been reported to occur in neurological disorders. These alterations result in changes in membrane fluidity and permeability. These processes along with the accumulation of lipid peroxides and compromised energy metabolism may be responsible for the neurodegeneration observed in neurological disorders. SN - 0009-3084 UR - https://www.unboundmedicine.com/medline/citation/10878232/Glycerophospholipids_in_brain:_their_metabolism_incorporation_into_membranes_functions_and_involvement_in_neurological_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-3084(00)00128-6 DB - PRIME DP - Unbound Medicine ER -