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Age related seroprevalence of antibodies to hepatitis A virus in Hyderabad, India.
Trop Gastroenterol. 2000 Apr-Jun; 21(2):63-5.TG

Abstract

BACKGROUND

Hepatitis A virus (HAV) is an enterically transmitted viral disease endemic in many developing countries including India. Infection is often subclinical or asymptomatic in children while with increasing age symptomatic acute infections are more common. In some developing countries improvements in living conditions have led to change in epidemiology of HAV infection. In our country there are very few reports on prevalence of HAV.

OBJECTIVE

The present study was undertaken to determine the seroprevalence of hepatitis A virus antibodies in relation to age in Hyderabad.

MATERIAL AND METHODS

Serum samples were collected from 90 subjects in the age group 2-64 years in a mass vaccination camp for Hepatitis B. All the subjects were investigated with a uniform social and medical history questionnaire. Sera were tested for antibody to HAV (total anti-HAV) using enzyme immunoassay (General Biologicals, Taiwan).

RESULTS

The subjects included 48 males and 42 females. There were 54 children (< 12 yrs) and 36 adults. Of the 90 serum samples tested 51 (56%) were positive for anti HAV antibodies. The seropositivity in males and females was similar. The seroprevalence was 31.8% (17/54) in children (< 12 years) and 94.4% (34/36) in adults (p < 0.001). Age related seroprevalence revealed that a majority of children below 10 years (33/48, 69%) remain anti HAV negative, while only 25% of children below 15 years were anti HAV negative. The anti HAV antibody positivity was similar in different income groups.

CONCLUSION

The prevalence of HAV is high in Hyderabad. A majority of children below 10 years and 25% of children < 15 years remain susceptible to HAV infection. Child immunization against HAV therefore should be considered in our population too.

Authors+Show Affiliations

Department of Gastroenterology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10881625

Citation

Joshi, N, et al. "Age Related Seroprevalence of Antibodies to Hepatitis a Virus in Hyderabad, India." Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, vol. 21, no. 2, 2000, pp. 63-5.
Joshi N, Yr NK, Kumar A. Age related seroprevalence of antibodies to hepatitis A virus in Hyderabad, India. Trop Gastroenterol. 2000;21(2):63-5.
Joshi, N., Yr, N. K., & Kumar, A. (2000). Age related seroprevalence of antibodies to hepatitis A virus in Hyderabad, India. Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, 21(2), 63-5.
Joshi N, Yr NK, Kumar A. Age Related Seroprevalence of Antibodies to Hepatitis a Virus in Hyderabad, India. Trop Gastroenterol. 2000 Apr-Jun;21(2):63-5. PubMed PMID: 10881625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age related seroprevalence of antibodies to hepatitis A virus in Hyderabad, India. AU - Joshi,N, AU - Yr,N K, AU - Kumar,A, PY - 2000/7/6/pubmed PY - 2000/8/6/medline PY - 2000/7/6/entrez SP - 63 EP - 5 JF - Tropical gastroenterology : official journal of the Digestive Diseases Foundation JO - Trop Gastroenterol VL - 21 IS - 2 N2 - BACKGROUND: Hepatitis A virus (HAV) is an enterically transmitted viral disease endemic in many developing countries including India. Infection is often subclinical or asymptomatic in children while with increasing age symptomatic acute infections are more common. In some developing countries improvements in living conditions have led to change in epidemiology of HAV infection. In our country there are very few reports on prevalence of HAV. OBJECTIVE: The present study was undertaken to determine the seroprevalence of hepatitis A virus antibodies in relation to age in Hyderabad. MATERIAL AND METHODS: Serum samples were collected from 90 subjects in the age group 2-64 years in a mass vaccination camp for Hepatitis B. All the subjects were investigated with a uniform social and medical history questionnaire. Sera were tested for antibody to HAV (total anti-HAV) using enzyme immunoassay (General Biologicals, Taiwan). RESULTS: The subjects included 48 males and 42 females. There were 54 children (< 12 yrs) and 36 adults. Of the 90 serum samples tested 51 (56%) were positive for anti HAV antibodies. The seropositivity in males and females was similar. The seroprevalence was 31.8% (17/54) in children (< 12 years) and 94.4% (34/36) in adults (p < 0.001). Age related seroprevalence revealed that a majority of children below 10 years (33/48, 69%) remain anti HAV negative, while only 25% of children below 15 years were anti HAV negative. The anti HAV antibody positivity was similar in different income groups. CONCLUSION: The prevalence of HAV is high in Hyderabad. A majority of children below 10 years and 25% of children < 15 years remain susceptible to HAV infection. Child immunization against HAV therefore should be considered in our population too. SN - 0250-636X UR - https://www.unboundmedicine.com/medline/citation/10881625/Age_related_seroprevalence_of_antibodies_to_hepatitis_A_virus_in_Hyderabad_India_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -