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Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women.
Lancet 2000; 355(9222):2185-8Lct

Abstract

BACKGROUND

Inhibitors of hydroxymethylglutaryl-coenzyme A reductase (statins) increase new bone formation in rodents and in human cells in vitro. Statin use is associated with increased bone mineral density of the femoral neck. We undertook a population-based case-control study at six health-maintenance organisations in the USA to investigate further the relation between statin use and fracture risk among older women.

METHODS

We investigated women aged 60 years or older. Exposure, outcome, and confounder information was obtained from automated claims and pharmacy data from October, 1994, to September, 1997. Cases had an incident diagnosis of non-pathological fracture of the hip, humerus, distal tibia, wrist, or vertebrae between October, 1996, and September, 1997. Controls had no fracture during this period. We excluded women with records of dispensing of drugs to treat osteoporosis.

FINDINGS

There were 928 cases and 2747 controls. Compared with women who had no record of statin dispensing during the previous 2 years, women with 13 or more statin dispensings during this period had a decreased risk of non-pathological fracture (odds ratio 0.48 [95% CI 0.27-0.83]) after adjustment for age, number of hospital admissions during the previous year, chronic disease score, and use of non-statin lipid-lowering drugs. No association was found between fracture risk and fewer than 13 dispensings of statins or between fracture risk and use of non-statin lipid-lowering drugs.

INTERPRETATION

Statins seem to be protective against non-pathological fracture among older women. These findings are compatible with the hypothesis that statins increase bone mineral density in human beings and thereby decrease the risk of osteoporotic fractures.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. kachan@epinet.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

10881890

Citation

Chan, K A., et al. "Inhibitors of Hydroxymethylglutaryl-coenzyme a Reductase and Risk of Fracture Among Older Women." Lancet (London, England), vol. 355, no. 9222, 2000, pp. 2185-8.
Chan KA, Andrade SE, Boles M, et al. Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. Lancet. 2000;355(9222):2185-8.
Chan, K. A., Andrade, S. E., Boles, M., Buist, D. S., Chase, G. A., Donahue, J. G., ... Platt, R. (2000). Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. Lancet (London, England), 355(9222), pp. 2185-8.
Chan KA, et al. Inhibitors of Hydroxymethylglutaryl-coenzyme a Reductase and Risk of Fracture Among Older Women. Lancet. 2000 Jun 24;355(9222):2185-8. PubMed PMID: 10881890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. AU - Chan,K A, AU - Andrade,S E, AU - Boles,M, AU - Buist,D S, AU - Chase,G A, AU - Donahue,J G, AU - Goodman,M J, AU - Gurwitz,J H, AU - LaCroix,A Z, AU - Platt,R, PY - 2000/7/6/pubmed PY - 2000/7/6/medline PY - 2000/7/6/entrez SP - 2185 EP - 8 JF - Lancet (London, England) JO - Lancet VL - 355 IS - 9222 N2 - BACKGROUND: Inhibitors of hydroxymethylglutaryl-coenzyme A reductase (statins) increase new bone formation in rodents and in human cells in vitro. Statin use is associated with increased bone mineral density of the femoral neck. We undertook a population-based case-control study at six health-maintenance organisations in the USA to investigate further the relation between statin use and fracture risk among older women. METHODS: We investigated women aged 60 years or older. Exposure, outcome, and confounder information was obtained from automated claims and pharmacy data from October, 1994, to September, 1997. Cases had an incident diagnosis of non-pathological fracture of the hip, humerus, distal tibia, wrist, or vertebrae between October, 1996, and September, 1997. Controls had no fracture during this period. We excluded women with records of dispensing of drugs to treat osteoporosis. FINDINGS: There were 928 cases and 2747 controls. Compared with women who had no record of statin dispensing during the previous 2 years, women with 13 or more statin dispensings during this period had a decreased risk of non-pathological fracture (odds ratio 0.48 [95% CI 0.27-0.83]) after adjustment for age, number of hospital admissions during the previous year, chronic disease score, and use of non-statin lipid-lowering drugs. No association was found between fracture risk and fewer than 13 dispensings of statins or between fracture risk and use of non-statin lipid-lowering drugs. INTERPRETATION: Statins seem to be protective against non-pathological fracture among older women. These findings are compatible with the hypothesis that statins increase bone mineral density in human beings and thereby decrease the risk of osteoporotic fractures. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/10881890/Inhibitors_of_hydroxymethylglutaryl_coenzyme_A_reductase_and_risk_of_fracture_among_older_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(00)02400-4 DB - PRIME DP - Unbound Medicine ER -