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Identification of 2 novel isolates of hepatitis E virus in Argentina.
J Infect Dis. 2000 Jul; 182(1):294-7.JI

Abstract

Hepatitis E virus (HEV) has been identified in 2 Argentine patients with acute hepatitis who reported no history of travel to regions in which HEV is considered endemic. These isolates are the first to be identified in South America. By use of degenerate primers from open reading frames 1 and 2, HEV sequences were obtained from these patients' serum and compared with published HEV sequences. The Argentine isolates are different from all previously identified HEV isolates and are most closely related to each other. The Argentine isolates are distinct from the most geographically related isolate from Mexico as well as isolates from other endemic (China, Southeast Asia, and India) and nonendemic (the United States and Europe) regions. Phylogenetic analysis indicate that the Argentine isolates represent a new genotype of HEV, genotype 8, distinct from the Burmese-like genotype 1, Mexican genotype 2, US genotype 3, Chinese/Taiwan genotype 4, and European genotypes 5-7.

Authors+Show Affiliations

Virus Discovery Group, Abbott Laboratories, North Chicago, IL 60064-6269. george.schlauder@add.ssw.abbott.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10882610

Citation

Schlauder, G G., et al. "Identification of 2 Novel Isolates of Hepatitis E Virus in Argentina." The Journal of Infectious Diseases, vol. 182, no. 1, 2000, pp. 294-7.
Schlauder GG, Frider B, Sookoian S, et al. Identification of 2 novel isolates of hepatitis E virus in Argentina. J Infect Dis. 2000;182(1):294-7.
Schlauder, G. G., Frider, B., Sookoian, S., Castaño, G. C., & Mushahwar, I. K. (2000). Identification of 2 novel isolates of hepatitis E virus in Argentina. The Journal of Infectious Diseases, 182(1), 294-7.
Schlauder GG, et al. Identification of 2 Novel Isolates of Hepatitis E Virus in Argentina. J Infect Dis. 2000;182(1):294-7. PubMed PMID: 10882610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of 2 novel isolates of hepatitis E virus in Argentina. AU - Schlauder,G G, AU - Frider,B, AU - Sookoian,S, AU - Castaño,G C, AU - Mushahwar,I K, Y1 - 2000/07/06/ PY - 2000/01/21/received PY - 2000/03/29/revised PY - 2000/7/7/pubmed PY - 2000/10/3/medline PY - 2000/7/7/entrez SP - 294 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 182 IS - 1 N2 - Hepatitis E virus (HEV) has been identified in 2 Argentine patients with acute hepatitis who reported no history of travel to regions in which HEV is considered endemic. These isolates are the first to be identified in South America. By use of degenerate primers from open reading frames 1 and 2, HEV sequences were obtained from these patients' serum and compared with published HEV sequences. The Argentine isolates are different from all previously identified HEV isolates and are most closely related to each other. The Argentine isolates are distinct from the most geographically related isolate from Mexico as well as isolates from other endemic (China, Southeast Asia, and India) and nonendemic (the United States and Europe) regions. Phylogenetic analysis indicate that the Argentine isolates represent a new genotype of HEV, genotype 8, distinct from the Burmese-like genotype 1, Mexican genotype 2, US genotype 3, Chinese/Taiwan genotype 4, and European genotypes 5-7. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10882610/Identification_of_2_novel_isolates_of_hepatitis_E_virus_in_Argentina_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315651 DB - PRIME DP - Unbound Medicine ER -