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Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better heartburn relief than antacids.
Aliment Pharmacol Ther. 2000 Jul; 14(7):911-8.AP

Abstract

BACKGROUND

Many individuals with heartburn self-medicate with antacids for relief of their symptoms.

AIM

To compare efficacy of effervescent ranitidine to as-needed calcium carbonate antacids in subjects who self-treat heartburn.

METHODS

A total of 155 subjects with frequent antacid-responsive heartburn were randomized to receive effervescent ranitidine 150 mg tablets b.d., or as-needed calcium carbonate 750 mg for 12 weeks. Endoscopic oesophagitis severity and mucosal histology were assessed at baseline, and at weeks 6 and 12. Heartburn frequency, severity, and antacid consumption were recorded daily, and quality of life was assessed at baseline, and at weeks 6 and 12.

RESULTS

Heartburn frequency and severity were significantly decreased after 1 day of ranitidine (P < 0.02). By week 6, ranitidine had significantly decreased rescue antacid consumption (7.3 tablets, P < 0.001) vs. antacids (14.1 tablets). Endoscopic oesophagitis healing (</= grade 1) was significantly better with ranitidine (55%, P=0.022) vs. antacids (29%). Quality of life was improved by both treatments; however, ranitidine was numerically superior for all quality of life parameters, statistically superior for several quality of life indices at week 6 and for the pain-related index by week 12 (P < 0. 05).

CONCLUSIONS

For subjects self-administering antacids for chronic heartburn, effervescent ranitidine 150 mg b.d. is more effective than antacids in reducing heartburn, healing erosive oesophagitis, alleviating pain, and improving quality of life.

Authors+Show Affiliations

University of Arizona Health Sciences Center, Tucson, AZ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10886047

Citation

Earnest, D, et al. "Managing Heartburn at the 'base' of the GERD 'iceberg': Effervescent Ranitidine 150 Mg B.d. Provides Faster and Better Heartburn Relief Than Antacids." Alimentary Pharmacology & Therapeutics, vol. 14, no. 7, 2000, pp. 911-8.
Earnest D, Robinson M, Rodriguez-Stanley S, et al. Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better heartburn relief than antacids. Aliment Pharmacol Ther. 2000;14(7):911-8.
Earnest, D., Robinson, M., Rodriguez-Stanley, S., Ciociola, A. A., Jaffe, P., Silver, M. T., Kleoudis, C. S., & Murdock, R. H. (2000). Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better heartburn relief than antacids. Alimentary Pharmacology & Therapeutics, 14(7), 911-8.
Earnest D, et al. Managing Heartburn at the 'base' of the GERD 'iceberg': Effervescent Ranitidine 150 Mg B.d. Provides Faster and Better Heartburn Relief Than Antacids. Aliment Pharmacol Ther. 2000;14(7):911-8. PubMed PMID: 10886047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better heartburn relief than antacids. AU - Earnest,D, AU - Robinson,M, AU - Rodriguez-Stanley,S, AU - Ciociola,A A, AU - Jaffe,P, AU - Silver,M T, AU - Kleoudis,C S, AU - Murdock,R H, PY - 2000/7/25/pubmed PY - 2000/10/7/medline PY - 2000/7/25/entrez SP - 911 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 14 IS - 7 N2 - BACKGROUND: Many individuals with heartburn self-medicate with antacids for relief of their symptoms. AIM: To compare efficacy of effervescent ranitidine to as-needed calcium carbonate antacids in subjects who self-treat heartburn. METHODS: A total of 155 subjects with frequent antacid-responsive heartburn were randomized to receive effervescent ranitidine 150 mg tablets b.d., or as-needed calcium carbonate 750 mg for 12 weeks. Endoscopic oesophagitis severity and mucosal histology were assessed at baseline, and at weeks 6 and 12. Heartburn frequency, severity, and antacid consumption were recorded daily, and quality of life was assessed at baseline, and at weeks 6 and 12. RESULTS: Heartburn frequency and severity were significantly decreased after 1 day of ranitidine (P < 0.02). By week 6, ranitidine had significantly decreased rescue antacid consumption (7.3 tablets, P < 0.001) vs. antacids (14.1 tablets). Endoscopic oesophagitis healing (</= grade 1) was significantly better with ranitidine (55%, P=0.022) vs. antacids (29%). Quality of life was improved by both treatments; however, ranitidine was numerically superior for all quality of life parameters, statistically superior for several quality of life indices at week 6 and for the pain-related index by week 12 (P < 0. 05). CONCLUSIONS: For subjects self-administering antacids for chronic heartburn, effervescent ranitidine 150 mg b.d. is more effective than antacids in reducing heartburn, healing erosive oesophagitis, alleviating pain, and improving quality of life. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10886047/Managing_heartburn_at_the_'base'_of_the_GERD_'iceberg':_effervescent_ranitidine_150_mg_b_d__provides_faster_and_better_heartburn_relief_than_antacids_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2000&amp;volume=14&amp;issue=7&amp;spage=911 DB - PRIME DP - Unbound Medicine ER -