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Holt-Oram syndrome revisited. Two patients in the same family.
Arq Bras Cardiol. 1999 Nov; 73(5):429-34.AB

Abstract

Holt-Oram syndrome was first described in 1960 as an association of familial heart disease and musculoskeletal abnormalities. The most important findings include atrial septal defects, atrioventricular conduction abnormalities, vascular hypoplasia, and upper limb musculoskeletal deformities. We report two patients with this syndrome in the same family and discuss the variability of the musculoskeletal abnormalities and their association with the cardiac morphologic defects. Both patients in this study had associated eosinophilia, which has not been reported in the literature.

Authors+Show Affiliations

Hospital São Francisco da Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10887363

Citation

Frota Filho, J D., et al. "Holt-Oram Syndrome Revisited. Two Patients in the Same Family." Arquivos Brasileiros De Cardiologia, vol. 73, no. 5, 1999, pp. 429-34.
Frota Filho JD, Pereira W, Leiria TL, et al. Holt-Oram syndrome revisited. Two patients in the same family. Arq Bras Cardiol. 1999;73(5):429-34.
Frota Filho, J. D., Pereira, W., Leiria, T. L., Vallenas, M., Leães, P. E., Blacher, C., Lúcio, E., & Lucchese, F. A. (1999). Holt-Oram syndrome revisited. Two patients in the same family. Arquivos Brasileiros De Cardiologia, 73(5), 429-34.
Frota Filho JD, et al. Holt-Oram Syndrome Revisited. Two Patients in the Same Family. Arq Bras Cardiol. 1999;73(5):429-34. PubMed PMID: 10887363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Holt-Oram syndrome revisited. Two patients in the same family. AU - Frota Filho,J D, AU - Pereira,W, AU - Leiria,T L, AU - Vallenas,M, AU - Leães,P E, AU - Blacher,C, AU - Lúcio,E, AU - Lucchese,F A, PY - 2000/7/11/pubmed PY - 2000/8/19/medline PY - 2000/7/11/entrez SP - 429 EP - 34 JF - Arquivos brasileiros de cardiologia JO - Arq Bras Cardiol VL - 73 IS - 5 N2 - Holt-Oram syndrome was first described in 1960 as an association of familial heart disease and musculoskeletal abnormalities. The most important findings include atrial septal defects, atrioventricular conduction abnormalities, vascular hypoplasia, and upper limb musculoskeletal deformities. We report two patients with this syndrome in the same family and discuss the variability of the musculoskeletal abnormalities and their association with the cardiac morphologic defects. Both patients in this study had associated eosinophilia, which has not been reported in the literature. SN - 0066-782X UR - https://www.unboundmedicine.com/medline/citation/10887363/Holt_Oram_syndrome_revisited__Two_patients_in_the_same_family_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X1999001100003&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -