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Excess triiodothyronine as a risk factor of coronary events.
Arch Intern Med. 2000 Jul 10; 160(13):1993-9.AI

Abstract

BACKGROUND

Abnormalities in cardiac function, eg, arrhythmias and congestive heart failure, often accompany thyrotoxicosis. A relationship between thyroid hormone excess and the cardiac complications of angina pectoris and myocardial infarction (MI) remains largely speculative.

METHODS

The results of thyroid function studies on blood samples drawn from a total of 1049 patients (aged 40 years or older) immediately on emergency medical admission were related to frequencies of angina pectoris and myocardial infarction as determined according to current diagnostic algorithms. After 3 years, those patients who had initially presented with angina pectoris or acute MI were observed for subsequent coronary events; of these (n=185), 98% of the subjects (n=181) could be reevaluated.

RESULTS

On hospital admission, the relative rate of angina pectoris and MI was markedly high (odds ratio, 2.6; 95% confidence interval, 1.3-5.2; P=.007) in patients with elevated serum free and total triiodothyronine (T(3)) levels. An initially elevated free T(3) level was a risk factor for subsequent coronary events during the 3-year follow-up (adjusted odds ratio, 4.8; 95% confidence interval, 1.3-17.4; P=.02).

CONCLUSIONS

An elevation of serum free T(3) levels at hospital admission is associated with a 2.6-fold greater likelihood of the presence of a coronary event. Moreover, an initially elevated T(3) level is associated with a 3-fold higher risk of developing a subsequent coronary event during the next 3 years. Excess T(3) seemed to be a factor associated with the development and progression of acute myocardial ischemia.

Authors+Show Affiliations

Medical Clinic 1, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10888973

Citation

Peters, A, et al. "Excess Triiodothyronine as a Risk Factor of Coronary Events." Archives of Internal Medicine, vol. 160, no. 13, 2000, pp. 1993-9.
Peters A, Ehlers M, Blank B, et al. Excess triiodothyronine as a risk factor of coronary events. Arch Intern Med. 2000;160(13):1993-9.
Peters, A., Ehlers, M., Blank, B., Exler, D., Falk, C., Kohlmann, T., Fruehwald-Schultes, B., Wellhoener, P., Kerner, W., & Fehm, H. L. (2000). Excess triiodothyronine as a risk factor of coronary events. Archives of Internal Medicine, 160(13), 1993-9.
Peters A, et al. Excess Triiodothyronine as a Risk Factor of Coronary Events. Arch Intern Med. 2000 Jul 10;160(13):1993-9. PubMed PMID: 10888973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excess triiodothyronine as a risk factor of coronary events. AU - Peters,A, AU - Ehlers,M, AU - Blank,B, AU - Exler,D, AU - Falk,C, AU - Kohlmann,T, AU - Fruehwald-Schultes,B, AU - Wellhoener,P, AU - Kerner,W, AU - Fehm,H L, PY - 2000/7/11/pubmed PY - 2000/7/11/medline PY - 2000/7/11/entrez SP - 1993 EP - 9 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 160 IS - 13 N2 - BACKGROUND: Abnormalities in cardiac function, eg, arrhythmias and congestive heart failure, often accompany thyrotoxicosis. A relationship between thyroid hormone excess and the cardiac complications of angina pectoris and myocardial infarction (MI) remains largely speculative. METHODS: The results of thyroid function studies on blood samples drawn from a total of 1049 patients (aged 40 years or older) immediately on emergency medical admission were related to frequencies of angina pectoris and myocardial infarction as determined according to current diagnostic algorithms. After 3 years, those patients who had initially presented with angina pectoris or acute MI were observed for subsequent coronary events; of these (n=185), 98% of the subjects (n=181) could be reevaluated. RESULTS: On hospital admission, the relative rate of angina pectoris and MI was markedly high (odds ratio, 2.6; 95% confidence interval, 1.3-5.2; P=.007) in patients with elevated serum free and total triiodothyronine (T(3)) levels. An initially elevated free T(3) level was a risk factor for subsequent coronary events during the 3-year follow-up (adjusted odds ratio, 4.8; 95% confidence interval, 1.3-17.4; P=.02). CONCLUSIONS: An elevation of serum free T(3) levels at hospital admission is associated with a 2.6-fold greater likelihood of the presence of a coronary event. Moreover, an initially elevated T(3) level is associated with a 3-fold higher risk of developing a subsequent coronary event during the next 3 years. Excess T(3) seemed to be a factor associated with the development and progression of acute myocardial ischemia. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/10888973/Excess_triiodothyronine_as_a_risk_factor_of_coronary_events_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/160/pg/1993 DB - PRIME DP - Unbound Medicine ER -