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Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men?
Circulation. 2000 Jul 11; 102(2):179-84.Circ

Abstract

BACKGROUND

The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles).

METHODS AND RESULTS

Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values >/=90 cm and with elevated TG levels (>/=2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P<0.03) compared with men with low waist and TG levels.

CONCLUSIONS

It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.

Authors+Show Affiliations

Quebec Heart Institute, Laval Hospital Research Center, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10889128

Citation

Lemieux, I, et al. "Hypertriglyceridemic Waist: a Marker of the Atherogenic Metabolic Triad (hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?" Circulation, vol. 102, no. 2, 2000, pp. 179-84.
Lemieux I, Pascot A, Couillard C, et al. Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation. 2000;102(2):179-84.
Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud'homme, D., Nadeau, A., & Després, J. P. (2000). Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation, 102(2), 179-84.
Lemieux I, et al. Hypertriglyceridemic Waist: a Marker of the Atherogenic Metabolic Triad (hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men. Circulation. 2000 Jul 11;102(2):179-84. PubMed PMID: 10889128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? AU - Lemieux,I, AU - Pascot,A, AU - Couillard,C, AU - Lamarche,B, AU - Tchernof,A, AU - Alméras,N, AU - Bergeron,J, AU - Gaudet,D, AU - Tremblay,G, AU - Prud'homme,D, AU - Nadeau,A, AU - Després,J P, PY - 2000/7/13/pubmed PY - 2000/8/6/medline PY - 2000/7/13/entrez SP - 179 EP - 84 JF - Circulation JO - Circulation VL - 102 IS - 2 N2 - BACKGROUND: The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). METHODS AND RESULTS: Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values >/=90 cm and with elevated TG levels (>/=2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P<0.03) compared with men with low waist and TG levels. CONCLUSIONS: It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/10889128/Hypertriglyceridemic_waist:_A_marker_of_the_atherogenic_metabolic_triad__hyperinsulinemia L2 - https://www.ahajournals.org/doi/10.1161/01.cir.102.2.179?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -