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gamma-aminobutyric acid- and glycine-immunoreactive neurons postsynaptic to substance P-immunoreactive axon terminals in the superficial layers of the rat medullary dorsal horn.
Neurosci Lett. 2000 Jul 21; 288(3):187-90.NL

Abstract

gamma-Aminobutyric acid (GABA)ergic and glycinergic neurons were examined light- and electron-microscopically in laminae I and II of the medullary dorsal horn (MDH, i.e. spinal trigeminal nucleus caudalis in the rat). The majority of GABA- and glycine (Gly)-immunoreactive (-ir) neurons showed both GABA- and Gly-immunoreactivities (-IRs). Noxious stimulation (subcutaneous injection of formalin into perioral regions) induced Fos-IR in some of GABA- and Gly-ir neurons. GABA- and Gly-ir neuronal profiles were postsynaptic to substance P-ir axon terminals. These results suggest that nociceptive information being carried by primary afferent SP-fibers may be relayed directly to GABAergic and glycinergic neurons in laminae I and II of the MDH.

Authors+Show Affiliations

Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, 710032, PR, Xi'an, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10889339

Citation

Wang, D, et al. "Gamma-aminobutyric Acid- and Glycine-immunoreactive Neurons Postsynaptic to Substance P-immunoreactive Axon Terminals in the Superficial Layers of the Rat Medullary Dorsal Horn." Neuroscience Letters, vol. 288, no. 3, 2000, pp. 187-90.
Wang D, Li YQ, Li JL, et al. Gamma-aminobutyric acid- and glycine-immunoreactive neurons postsynaptic to substance P-immunoreactive axon terminals in the superficial layers of the rat medullary dorsal horn. Neurosci Lett. 2000;288(3):187-90.
Wang, D., Li, Y. Q., Li, J. L., Kaneko, T., Nomura, S., & Mizuno, N. (2000). Gamma-aminobutyric acid- and glycine-immunoreactive neurons postsynaptic to substance P-immunoreactive axon terminals in the superficial layers of the rat medullary dorsal horn. Neuroscience Letters, 288(3), 187-90.
Wang D, et al. Gamma-aminobutyric Acid- and Glycine-immunoreactive Neurons Postsynaptic to Substance P-immunoreactive Axon Terminals in the Superficial Layers of the Rat Medullary Dorsal Horn. Neurosci Lett. 2000 Jul 21;288(3):187-90. PubMed PMID: 10889339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - gamma-aminobutyric acid- and glycine-immunoreactive neurons postsynaptic to substance P-immunoreactive axon terminals in the superficial layers of the rat medullary dorsal horn. AU - Wang,D, AU - Li,Y Q, AU - Li,J L, AU - Kaneko,T, AU - Nomura,S, AU - Mizuno,N, PY - 2000/7/13/pubmed PY - 2000/9/30/medline PY - 2000/7/13/entrez SP - 187 EP - 90 JF - Neuroscience letters JO - Neurosci. Lett. VL - 288 IS - 3 N2 - gamma-Aminobutyric acid (GABA)ergic and glycinergic neurons were examined light- and electron-microscopically in laminae I and II of the medullary dorsal horn (MDH, i.e. spinal trigeminal nucleus caudalis in the rat). The majority of GABA- and glycine (Gly)-immunoreactive (-ir) neurons showed both GABA- and Gly-immunoreactivities (-IRs). Noxious stimulation (subcutaneous injection of formalin into perioral regions) induced Fos-IR in some of GABA- and Gly-ir neurons. GABA- and Gly-ir neuronal profiles were postsynaptic to substance P-ir axon terminals. These results suggest that nociceptive information being carried by primary afferent SP-fibers may be relayed directly to GABAergic and glycinergic neurons in laminae I and II of the MDH. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/10889339/gamma_aminobutyric_acid__and_glycine_immunoreactive_neurons_postsynaptic_to_substance_P_immunoreactive_axon_terminals_in_the_superficial_layers_of_the_rat_medullary_dorsal_horn_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S030439400001226X DB - PRIME DP - Unbound Medicine ER -