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Implantation defect in endometriosis: endometrium or peritoneal fluid.

Abstract

Clinical observations indicate that an implantation defect occurs in women with endometriosis. Despite intense research, the role of alterations in endometrial receptivity and the peritoneal fluid microenvironment in the derangement of implantation in endometriosis remains controversial. In this review, the evidence for the altered endometrial receptivity and peritoneal environment are summarized, and their effects on the implantation defect in women with endometriosis are discussed. Recent studies on cell adhesion molecules and their ligands, apoptosis, homeobox genes and the direct action of gonadotrophin-releasing hormone analogues are reviewed with respect to their contribution to endometrial receptivity in endometriosis. The possible mechanisms by which an altered peritoneal environment of endometriosis may affect implantation, including cytokine concentrations, iron metabolism, biochemical factors and embryotoxicity are discussed.

Authors+Show Affiliations

,

Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT 06520-8063, USA.

Source

MeSH

Apoptosis
Ascitic Fluid
Cell Adhesion Molecules
Embryo Implantation
Endometriosis
Endometrium
Female
Humans
Infertility, Female
Iron

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10889841

Citation

Selam, B, and A Arici. "Implantation Defect in Endometriosis: Endometrium or Peritoneal Fluid." Journal of Reproduction and Fertility. Supplement, vol. 55, 2000, pp. 121-8.
Selam B, Arici A. Implantation defect in endometriosis: endometrium or peritoneal fluid. J Reprod Fertil Suppl. 2000;55:121-8.
Selam, B., & Arici, A. (2000). Implantation defect in endometriosis: endometrium or peritoneal fluid. Journal of Reproduction and Fertility. Supplement, 55, pp. 121-8.
Selam B, Arici A. Implantation Defect in Endometriosis: Endometrium or Peritoneal Fluid. J Reprod Fertil Suppl. 2000;55:121-8. PubMed PMID: 10889841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implantation defect in endometriosis: endometrium or peritoneal fluid. AU - Selam,B, AU - Arici,A, PY - 2000/7/13/pubmed PY - 2000/7/25/medline PY - 2000/7/13/entrez SP - 121 EP - 8 JF - Journal of reproduction and fertility. Supplement JO - J. Reprod. Fertil. Suppl. VL - 55 N2 - Clinical observations indicate that an implantation defect occurs in women with endometriosis. Despite intense research, the role of alterations in endometrial receptivity and the peritoneal fluid microenvironment in the derangement of implantation in endometriosis remains controversial. In this review, the evidence for the altered endometrial receptivity and peritoneal environment are summarized, and their effects on the implantation defect in women with endometriosis are discussed. Recent studies on cell adhesion molecules and their ligands, apoptosis, homeobox genes and the direct action of gonadotrophin-releasing hormone analogues are reviewed with respect to their contribution to endometrial receptivity in endometriosis. The possible mechanisms by which an altered peritoneal environment of endometriosis may affect implantation, including cytokine concentrations, iron metabolism, biochemical factors and embryotoxicity are discussed. SN - 0449-3087 UR - https://www.unboundmedicine.com/medline/citation/10889841/Implantation_defect_in_endometriosis:_endometrium_or_peritoneal_fluid_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -