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Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients.
Arch Gen Psychiatry 2000; 57(7):692-9AG

Abstract

BACKGROUND

Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear.

METHODS

Magnetic resonance images were acquired using a 1.5-T magnet from 20 first-episode (at first hospitalization) patients with schizophrenia (mean age, 27.3 years), 24 first-episode patients with manic psychosis (mean age, 23.6 years), and 22 controls (mean age, 24.5 years). There was no significant difference in age for the 3 groups. All brain images were uniformly aligned and then reformatted and resampled to yield isotropic voxels.

RESULTS

Gray matter volume of the left planum temporale differed among the 3 groups. The patients with schizophrenia had significantly smaller left planum temporale volume than controls (20.0%) and patients with mania (20.0%). Heschl gyrus gray matter volume (left and right) was also reduced in patients with schizophrenia compared with controls (13.1%) and patients with bipolar mania (16.8%).

CONCLUSIONS

Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matter volume reduction. These findings are similar to those reported in patients with chronic schizophrenia and suggest that such abnormalities are present at first episode and are specific to schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Brockton Veterans Affairs Medical Center, and Harvard Medical School, Mass 02301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10891040

Citation

Hirayasu, Y, et al. "Planum Temporale and Heschl Gyrus Volume Reduction in Schizophrenia: a Magnetic Resonance Imaging Study of First-episode Patients." Archives of General Psychiatry, vol. 57, no. 7, 2000, pp. 692-9.
Hirayasu Y, McCarley RW, Salisbury DF, et al. Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. Arch Gen Psychiatry. 2000;57(7):692-9.
Hirayasu, Y., McCarley, R. W., Salisbury, D. F., Tanaka, S., Kwon, J. S., Frumin, M., ... Shenton, M. E. (2000). Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. Archives of General Psychiatry, 57(7), pp. 692-9.
Hirayasu Y, et al. Planum Temporale and Heschl Gyrus Volume Reduction in Schizophrenia: a Magnetic Resonance Imaging Study of First-episode Patients. Arch Gen Psychiatry. 2000;57(7):692-9. PubMed PMID: 10891040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. AU - Hirayasu,Y, AU - McCarley,R W, AU - Salisbury,D F, AU - Tanaka,S, AU - Kwon,J S, AU - Frumin,M, AU - Snyderman,D, AU - Yurgelun-Todd,D, AU - Kikinis,R, AU - Jolesz,F A, AU - Shenton,M E, PY - 2000/7/13/pubmed PY - 2000/7/25/medline PY - 2000/7/13/entrez SP - 692 EP - 9 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 57 IS - 7 N2 - BACKGROUND: Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear. METHODS: Magnetic resonance images were acquired using a 1.5-T magnet from 20 first-episode (at first hospitalization) patients with schizophrenia (mean age, 27.3 years), 24 first-episode patients with manic psychosis (mean age, 23.6 years), and 22 controls (mean age, 24.5 years). There was no significant difference in age for the 3 groups. All brain images were uniformly aligned and then reformatted and resampled to yield isotropic voxels. RESULTS: Gray matter volume of the left planum temporale differed among the 3 groups. The patients with schizophrenia had significantly smaller left planum temporale volume than controls (20.0%) and patients with mania (20.0%). Heschl gyrus gray matter volume (left and right) was also reduced in patients with schizophrenia compared with controls (13.1%) and patients with bipolar mania (16.8%). CONCLUSIONS: Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matter volume reduction. These findings are similar to those reported in patients with chronic schizophrenia and suggest that such abnormalities are present at first episode and are specific to schizophrenia. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/10891040/Planum_temporale_and_Heschl_gyrus_volume_reduction_in_schizophrenia:_a_magnetic_resonance_imaging_study_of_first_episode_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10891040.ui DB - PRIME DP - Unbound Medicine ER -