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[Etiologic diagnosis of viral meningitis. Study of 142 cases].
Acta Med Port. 1999 Dec; 12(12):341-4.AM

Abstract

Viral meningitis is a common disease, most often benign and striking predominantly children. In 1997, there was an outbreak of viral meningitis in the North of Portugal and this pathology accounted for 496 admissions to the Infectious Diseases Department of S. João Hospital. The authors' aim was to determine the etiology of the cases of viral meningitis admitted to the S. João Hospital by, in a first phase, searching enterovirus and serology for mumps in a sample of 142 patients with symptoms, signs and cerebrospinal fluid (CSF) cytochemical abnormalities typical of viral meningitis, in the absence of any bacterial or fungal growth (in blood and/or CSF) and with negative soluble bacterial antigens in CSF. The enterovirus was detected by polymerase chain reaction (PCR) and, in a small number of cases, by shell vial culture. The diagnosis of mumps was made by the detection of specific IgM antibodies in serum, using an enzyme-linked immunosorbent assay. The diagnosis was reached in 70 patients (49.3%): 47 (33.1%) had mumps meningitis and 23 (16.2%) enterovirus infection (PCR positive in all; culture positive in only 2 cases). In 72 patients (50.7%), the agent was not identified. Although only two agents were searched for, the diagnosis was made in a high proportion of cases. The culture method used for the isolation of enterovirus was found to have a low sensitivity.

Authors+Show Affiliations

Serviço de Doenças Infecciosas da Faculdade de Medicina do Porto e do Hospital de S. João.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

por

PubMed ID

10892436

Citation

Nogueira, J A., et al. "[Etiologic Diagnosis of Viral Meningitis. Study of 142 Cases]." Acta Medica Portuguesa, vol. 12, no. 12, 1999, pp. 341-4.
Nogueira JA, Simões J, Pontinha N, et al. [Etiologic diagnosis of viral meningitis. Study of 142 cases]. Acta Med Port. 1999;12(12):341-4.
Nogueira, J. A., Simões, J., Pontinha, N., Pinto, A., Freitas-Fonseca, A., & Lecour, H. (1999). [Etiologic diagnosis of viral meningitis. Study of 142 cases]. Acta Medica Portuguesa, 12(12), 341-4.
Nogueira JA, et al. [Etiologic Diagnosis of Viral Meningitis. Study of 142 Cases]. Acta Med Port. 1999;12(12):341-4. PubMed PMID: 10892436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Etiologic diagnosis of viral meningitis. Study of 142 cases]. AU - Nogueira,J A, AU - Simões,J, AU - Pontinha,N, AU - Pinto,A, AU - Freitas-Fonseca,A, AU - Lecour,H, PY - 2000/7/13/pubmed PY - 2000/8/12/medline PY - 2000/7/13/entrez SP - 341 EP - 4 JF - Acta medica portuguesa JO - Acta Med Port VL - 12 IS - 12 N2 - Viral meningitis is a common disease, most often benign and striking predominantly children. In 1997, there was an outbreak of viral meningitis in the North of Portugal and this pathology accounted for 496 admissions to the Infectious Diseases Department of S. João Hospital. The authors' aim was to determine the etiology of the cases of viral meningitis admitted to the S. João Hospital by, in a first phase, searching enterovirus and serology for mumps in a sample of 142 patients with symptoms, signs and cerebrospinal fluid (CSF) cytochemical abnormalities typical of viral meningitis, in the absence of any bacterial or fungal growth (in blood and/or CSF) and with negative soluble bacterial antigens in CSF. The enterovirus was detected by polymerase chain reaction (PCR) and, in a small number of cases, by shell vial culture. The diagnosis of mumps was made by the detection of specific IgM antibodies in serum, using an enzyme-linked immunosorbent assay. The diagnosis was reached in 70 patients (49.3%): 47 (33.1%) had mumps meningitis and 23 (16.2%) enterovirus infection (PCR positive in all; culture positive in only 2 cases). In 72 patients (50.7%), the agent was not identified. Although only two agents were searched for, the diagnosis was made in a high proportion of cases. The culture method used for the isolation of enterovirus was found to have a low sensitivity. SN - 0870-399X UR - https://www.unboundmedicine.com/medline/citation/10892436/[Etiologic_diagnosis_of_viral_meningitis__Study_of_142_cases]_ L2 - http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2167/1609 DB - PRIME DP - Unbound Medicine ER -