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Photopic negative response of the human ERG: losses associated with glaucomatous damage.
Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2205-11.IO

Abstract

PURPOSE

To evaluate in glaucomatous eyes the photopic electroretinogram (ERG) negative response (PhNR), a component that follows the b-wave peak and is thought to be correlated with inner retinal activity.

METHODS

Eleven patients with open-angle glaucoma (OAG) and moderate field loss (Humphrey 30-2 [Humphrey Instruments, San Leandro, CA] mean deviation < or = -6 dB), eight with ocular hypertension (OHT), and eight age-matched normal subjects were tested. Optic discs of patients and control subjects were evaluated by confocal scanning laser ophthalmoscopy. ERGs were recorded to long-duration stimuli (250 msec) of photopic luminance (78 candelas [cd] /m2), presented in the macular region (12 degrees x 12 degrees field size) on a steady, adapting background. Amplitudes of the a-wave and b-wave and the PhNR were measured. Pattern reversal ERGs to 30-minute checkerboards were also recorded from patients and control subjects.

RESULTS

Compared with control subjects, patients with OAG showed reduced PhNR (average reduction: 62%, P < 0.01), but normal a- and b-wave amplitudes. In patients with OHT, PhNR and a- and b-wave amplitudes did not differ from control values. In individual patients with OAG, PhNR amplitudes were correlated positively with pattern ERG amplitudes (r = 0.80; P < 0.01) and central (12 degrees) perimetric mean deviations (r = 0.68; P < 0.05) and negatively with cup-to-disc area ratios (r = -0.79; P < 0.01) and cup shape measures (r = -0.78; P < 0.01).

CONCLUSIONS

Similar to that found in monkeys with experimentally induced glaucoma, the PhNR is selectively altered in human glaucoma. The correlation between PhNR losses and clinical parameter abnormalities suggests that this component depends on inner retina integrity and may be of clinical value for detecting glaucomatous damage.

Authors+Show Affiliations

Institute of Ophthalmology, Catholic University, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10892864

Citation

Colotto, A, et al. "Photopic Negative Response of the Human ERG: Losses Associated With Glaucomatous Damage." Investigative Ophthalmology & Visual Science, vol. 41, no. 8, 2000, pp. 2205-11.
Colotto A, Falsini B, Salgarello T, et al. Photopic negative response of the human ERG: losses associated with glaucomatous damage. Invest Ophthalmol Vis Sci. 2000;41(8):2205-11.
Colotto, A., Falsini, B., Salgarello, T., Iarossi, G., Galan, M. E., & Scullica, L. (2000). Photopic negative response of the human ERG: losses associated with glaucomatous damage. Investigative Ophthalmology & Visual Science, 41(8), 2205-11.
Colotto A, et al. Photopic Negative Response of the Human ERG: Losses Associated With Glaucomatous Damage. Invest Ophthalmol Vis Sci. 2000;41(8):2205-11. PubMed PMID: 10892864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photopic negative response of the human ERG: losses associated with glaucomatous damage. AU - Colotto,A, AU - Falsini,B, AU - Salgarello,T, AU - Iarossi,G, AU - Galan,M E, AU - Scullica,L, PY - 2000/7/13/pubmed PY - 2000/8/6/medline PY - 2000/7/13/entrez SP - 2205 EP - 11 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 41 IS - 8 N2 - PURPOSE: To evaluate in glaucomatous eyes the photopic electroretinogram (ERG) negative response (PhNR), a component that follows the b-wave peak and is thought to be correlated with inner retinal activity. METHODS: Eleven patients with open-angle glaucoma (OAG) and moderate field loss (Humphrey 30-2 [Humphrey Instruments, San Leandro, CA] mean deviation < or = -6 dB), eight with ocular hypertension (OHT), and eight age-matched normal subjects were tested. Optic discs of patients and control subjects were evaluated by confocal scanning laser ophthalmoscopy. ERGs were recorded to long-duration stimuli (250 msec) of photopic luminance (78 candelas [cd] /m2), presented in the macular region (12 degrees x 12 degrees field size) on a steady, adapting background. Amplitudes of the a-wave and b-wave and the PhNR were measured. Pattern reversal ERGs to 30-minute checkerboards were also recorded from patients and control subjects. RESULTS: Compared with control subjects, patients with OAG showed reduced PhNR (average reduction: 62%, P < 0.01), but normal a- and b-wave amplitudes. In patients with OHT, PhNR and a- and b-wave amplitudes did not differ from control values. In individual patients with OAG, PhNR amplitudes were correlated positively with pattern ERG amplitudes (r = 0.80; P < 0.01) and central (12 degrees) perimetric mean deviations (r = 0.68; P < 0.05) and negatively with cup-to-disc area ratios (r = -0.79; P < 0.01) and cup shape measures (r = -0.78; P < 0.01). CONCLUSIONS: Similar to that found in monkeys with experimentally induced glaucoma, the PhNR is selectively altered in human glaucoma. The correlation between PhNR losses and clinical parameter abnormalities suggests that this component depends on inner retina integrity and may be of clinical value for detecting glaucomatous damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/10892864/Photopic_negative_response_of_the_human_ERG:_losses_associated_with_glaucomatous_damage_ L2 - https://iovs.arvojournals.org/article.aspx?volume=41&amp;issue=8&amp;page=2205 DB - PRIME DP - Unbound Medicine ER -