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Hormonal and biochemical parameters and osteoporotic fractures in elderly men.
J Bone Miner Res 2000; 15(7):1405-11JB

Abstract

Low testosterone has been associated with hip fracture in men in some studies. However, data on other hormonal parameters and fracture outcome in men is minimal. This study examined the association between free testosterone (free T) estradiol (E2), sex hormone-binding globulin (SHBG), 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), insulin-like growth factor I (IGF-I), and fracture in 437 elderly community-dwelling men. Age, height, weight, quadriceps strength, femoral neck bone mineral density (FN BMD), and fracture data (1989-1997) also were obtained. Fractures were classified as major (hip, pelvis, proximal tibia, multiple rib, vertebral, and proximal humerus) or minor (remaining distal upper and lower limb fractures). Fifty-four subjects had a fracture (24 major and 30 minor). There was no association between minor fractures and any hormonal parameter. Risk of major fracture was increased 2-fold for each SD increase in age, decrease in weight and height, and increase in SHBG, and risk of major fracture was increased 3-fold for each SD decrease in quadriceps strength, FN BMD, and 25(OH)D (univariate logistic regression). Independent predictors of major fracture were FN BMD, 2.7 (1.5-4.7; odds ratio [OR]) and 95% confidence interval [CI]); 25(OH)D, 2.8 (1.5-5.3); and SHBG, 1.7 (1.2-2.4). An abnormal value for three factors resulted in a 30-fold increase in risk but only affected 2% of the population. It is not immediately apparent how 25(OH)D and SHBG, largely independently of BMD, may contribute to fracture risk. They may be markers for biological age or health status not measured by methods that are more traditional and as such may be useful in identifying those at high risk of fracture.

Authors+Show Affiliations

Bone and Mineral Research Division, Garvan Institute of Medical Research, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10893691

Citation

Center, J R., et al. "Hormonal and Biochemical Parameters and Osteoporotic Fractures in Elderly Men." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 15, no. 7, 2000, pp. 1405-11.
Center JR, Nguyen TV, Sambrook PN, et al. Hormonal and biochemical parameters and osteoporotic fractures in elderly men. J Bone Miner Res. 2000;15(7):1405-11.
Center, J. R., Nguyen, T. V., Sambrook, P. N., & Eisman, J. A. (2000). Hormonal and biochemical parameters and osteoporotic fractures in elderly men. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 15(7), pp. 1405-11.
Center JR, et al. Hormonal and Biochemical Parameters and Osteoporotic Fractures in Elderly Men. J Bone Miner Res. 2000;15(7):1405-11. PubMed PMID: 10893691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal and biochemical parameters and osteoporotic fractures in elderly men. AU - Center,J R, AU - Nguyen,T V, AU - Sambrook,P N, AU - Eisman,J A, PY - 2000/7/14/pubmed PY - 2001/2/28/medline PY - 2000/7/14/entrez SP - 1405 EP - 11 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 15 IS - 7 N2 - Low testosterone has been associated with hip fracture in men in some studies. However, data on other hormonal parameters and fracture outcome in men is minimal. This study examined the association between free testosterone (free T) estradiol (E2), sex hormone-binding globulin (SHBG), 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), insulin-like growth factor I (IGF-I), and fracture in 437 elderly community-dwelling men. Age, height, weight, quadriceps strength, femoral neck bone mineral density (FN BMD), and fracture data (1989-1997) also were obtained. Fractures were classified as major (hip, pelvis, proximal tibia, multiple rib, vertebral, and proximal humerus) or minor (remaining distal upper and lower limb fractures). Fifty-four subjects had a fracture (24 major and 30 minor). There was no association between minor fractures and any hormonal parameter. Risk of major fracture was increased 2-fold for each SD increase in age, decrease in weight and height, and increase in SHBG, and risk of major fracture was increased 3-fold for each SD decrease in quadriceps strength, FN BMD, and 25(OH)D (univariate logistic regression). Independent predictors of major fracture were FN BMD, 2.7 (1.5-4.7; odds ratio [OR]) and 95% confidence interval [CI]); 25(OH)D, 2.8 (1.5-5.3); and SHBG, 1.7 (1.2-2.4). An abnormal value for three factors resulted in a 30-fold increase in risk but only affected 2% of the population. It is not immediately apparent how 25(OH)D and SHBG, largely independently of BMD, may contribute to fracture risk. They may be markers for biological age or health status not measured by methods that are more traditional and as such may be useful in identifying those at high risk of fracture. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/10893691/Hormonal_and_biochemical_parameters_and_osteoporotic_fractures_in_elderly_men_ L2 - https://doi.org/10.1359/jbmr.2000.15.7.1405 DB - PRIME DP - Unbound Medicine ER -