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Effect of glucagon on meal-induced gastric secretion in man.
Gastroenterology. 1975 Mar; 68(3):448-54.G

Abstract

The effect of glucagon on gastric acid and pepsin secretion, basal or stimulated by a meal, pentagastrin and histamine, was studied in duodenal ulcer patients. Intravenous glucagon infused in graded doses ranging from 6.2 to 50 mug per kg-hr produced a dose-related inhibition of pentagastrin-induced acid secretion reaching about 40% of the control level at the dose of 50 mug per kg-hr. Acid inhibition was paralleled by a decrease in the pepsin output and serum calcium level and was accompanied by a rise in the blood glucose concentration. Glucagon used in a standard dose of 25 mug per kg-hr produced about 50% inhibition of acid secretion induced by a meal (measured by intragastric titration) accompanied by a significant decrease in the serum gastrin level measured by radioimmunoassay. Histamine-induced secretion was only slightly inhibited by glucagon, and the degree of inhibition for acid (25%) and pepsin (20%) secretion was statistically insignificant.

Authors

Konturek SJ
No affiliation info available
Biernat J
No affiliation info available
Kwiecień N
No affiliation info available
Oleksy J
No affiliation info available

MeSH

AdultDose-Response Relationship, DrugDuodenal UlcerFoodGastric Acidity DeterminationGastric JuiceGastric MucosaGastrinsGlucagonHistamineHumansInjections, IntravenousPentagastrinPepsin ARadioimmunoassaySecretory Rate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1089577

Citation

Konturek, S J., et al. "Effect of Glucagon On Meal-induced Gastric Secretion in Man." Gastroenterology, vol. 68, no. 3, 1975, pp. 448-54.
Konturek SJ, Biernat J, Kwiecień N, et al. Effect of glucagon on meal-induced gastric secretion in man. Gastroenterology. 1975;68(3):448-54.
Konturek, S. J., Biernat, J., Kwiecień, N., & Oleksy, J. (1975). Effect of glucagon on meal-induced gastric secretion in man. Gastroenterology, 68(3), 448-54.
Konturek SJ, et al. Effect of Glucagon On Meal-induced Gastric Secretion in Man. Gastroenterology. 1975;68(3):448-54. PubMed PMID: 1089577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glucagon on meal-induced gastric secretion in man. AU - Konturek,S J, AU - Biernat,J, AU - Kwiecień,N, AU - Oleksy,J, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 448 EP - 54 JF - Gastroenterology JO - Gastroenterology VL - 68 IS - 3 N2 - The effect of glucagon on gastric acid and pepsin secretion, basal or stimulated by a meal, pentagastrin and histamine, was studied in duodenal ulcer patients. Intravenous glucagon infused in graded doses ranging from 6.2 to 50 mug per kg-hr produced a dose-related inhibition of pentagastrin-induced acid secretion reaching about 40% of the control level at the dose of 50 mug per kg-hr. Acid inhibition was paralleled by a decrease in the pepsin output and serum calcium level and was accompanied by a rise in the blood glucose concentration. Glucagon used in a standard dose of 25 mug per kg-hr produced about 50% inhibition of acid secretion induced by a meal (measured by intragastric titration) accompanied by a significant decrease in the serum gastrin level measured by radioimmunoassay. Histamine-induced secretion was only slightly inhibited by glucagon, and the degree of inhibition for acid (25%) and pepsin (20%) secretion was statistically insignificant. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1089577/Effect_of_glucagon_on_meal_induced_gastric_secretion_in_man_ DB - PRIME DP - Unbound Medicine ER -