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Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease.
Thromb Haemost. 2000 Jun; 83(6):853-60.TH

Abstract

Bronchoalveolar lavage fluids (BALF) from patients with hypersensitivity pneumonitis (HP; n = 35), idiopathic pulmonary fibrosis (IPF, n = 41) and sarcoidosis (SARC, n = 48) were investigated for alterations in the alveolar hemostatic balance. Healthy individuals (n = 21) served as Controls. Procoagulant activity (PCA), tissue factor (TF) activity and F VII activity were assessed by means of specific recalcification assays. The overall fibrinolytic activity (FA) was measured using the (125)I-labeled fibrin plate assay. Fibrinopeptide A (FP-A), D-Dimer, plasminogen activators (PA) of the urokinase (u-PA) or tissue type (t-PA), PA-inhibitor I (PAI-1) and alpha2-antiplasmin (alpha2-AP) were determined by ELISA technique. As compared to Controls, all groups with interstitial lung disease (ILD) displayed an increase in BALF PCA by approximately one order of magnitude, and this was ascribed to enhanced TF activity by >98%. Accordingly, F VII-activity was increased in all ILD groups, and elevated FP-A levels were noted. There was no significant difference in procoagulant activities between the different ILD entities, but the increase in TF was significantly correlated with deterioration of lung compliance. Overall fibrinolytic activity did not significantly differ between ILD entities and Controls, although some reduction in IPF subjects was observed. Nevertheless, changes in the profile of the different pro- and antifibrinolytic compounds were noted. U-PA, but not t-PA levels were significantly reduced in all ILD groups. alpha2-AP was markedly elevated throughout, whereas PAI-1 levels were lowered. As a balance of

Authors+Show Affiliations

Dept. of Internal Medicine, Justus-Liebig-University, Giessen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10896238

Citation

Günther, A, et al. "Enhanced Tissue Factor Pathway Activity and Fibrin Turnover in the Alveolar Compartment of Patients With Interstitial Lung Disease." Thrombosis and Haemostasis, vol. 83, no. 6, 2000, pp. 853-60.
Günther A, Mosavi P, Ruppert C, et al. Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease. Thromb Haemost. 2000;83(6):853-60.
Günther, A., Mosavi, P., Ruppert, C., Heinemann, S., Temmesfeld, B., Velcovsky, H. G., Morr, H., Grimminger, F., Walmrath, D., & Seeger, W. (2000). Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease. Thrombosis and Haemostasis, 83(6), 853-60.
Günther A, et al. Enhanced Tissue Factor Pathway Activity and Fibrin Turnover in the Alveolar Compartment of Patients With Interstitial Lung Disease. Thromb Haemost. 2000;83(6):853-60. PubMed PMID: 10896238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease. AU - Günther,A, AU - Mosavi,P, AU - Ruppert,C, AU - Heinemann,S, AU - Temmesfeld,B, AU - Velcovsky,H G, AU - Morr,H, AU - Grimminger,F, AU - Walmrath,D, AU - Seeger,W, PY - 2000/7/15/pubmed PY - 2001/2/28/medline PY - 2000/7/15/entrez SP - 853 EP - 60 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 83 IS - 6 N2 - Bronchoalveolar lavage fluids (BALF) from patients with hypersensitivity pneumonitis (HP; n = 35), idiopathic pulmonary fibrosis (IPF, n = 41) and sarcoidosis (SARC, n = 48) were investigated for alterations in the alveolar hemostatic balance. Healthy individuals (n = 21) served as Controls. Procoagulant activity (PCA), tissue factor (TF) activity and F VII activity were assessed by means of specific recalcification assays. The overall fibrinolytic activity (FA) was measured using the (125)I-labeled fibrin plate assay. Fibrinopeptide A (FP-A), D-Dimer, plasminogen activators (PA) of the urokinase (u-PA) or tissue type (t-PA), PA-inhibitor I (PAI-1) and alpha2-antiplasmin (alpha2-AP) were determined by ELISA technique. As compared to Controls, all groups with interstitial lung disease (ILD) displayed an increase in BALF PCA by approximately one order of magnitude, and this was ascribed to enhanced TF activity by >98%. Accordingly, F VII-activity was increased in all ILD groups, and elevated FP-A levels were noted. There was no significant difference in procoagulant activities between the different ILD entities, but the increase in TF was significantly correlated with deterioration of lung compliance. Overall fibrinolytic activity did not significantly differ between ILD entities and Controls, although some reduction in IPF subjects was observed. Nevertheless, changes in the profile of the different pro- and antifibrinolytic compounds were noted. U-PA, but not t-PA levels were significantly reduced in all ILD groups. alpha2-AP was markedly elevated throughout, whereas PAI-1 levels were lowered. As a balance of SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/10896238/Enhanced_tissue_factor_pathway_activity_and_fibrin_turnover_in_the_alveolar_compartment_of_patients_with_interstitial_lung_disease_ L2 - http://www.diseaseinfosearch.org/result/3844 DB - PRIME DP - Unbound Medicine ER -