[Therapy of androgenetic alopecia with finasteride. What must be considered in consultation and drug prescribing].
MMW Fortschr Med. 1999 Sep 16; 141(37):38-40.MF

Abstract

Androgenetic alopecia in men is genetically determined, but occurs only when the testosterone metabolite dihydrotestosterone (DHT) is present in normal levels. The drug, finasteride, inhibits the enzyme 5-alpha-reductase II, which is responsible for converting testosterone to DHT. One 1 mg tablet (Propecia) of finasteride daily lowers serum DHT levels by about 70%, and increases serum testosterone by 10%. The efficacy of finasteride 1 mg has been demonstrated in a randomized, double-blind, placebo-controlled clinical trial involving more than 1,500 men in whom a significant increase in hair density over a specified area of the scalp, and a significant improvement in appearance was noted. Following one year to treatment 48%, and following 2 years 66%, of the finasteride patients (placebo group 7% after both treatment periods) presented with visibly thicker hair growth. Side effects such as decreased libido, ejaculation disorders and erectile dysfunction were seen in fewer than 2% of the men in both the finasteride and placebo groups.

Authors+Show Affiliations

Wolff H

Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München. hans.wolff@lrz.uni-muenchen.de

Kunte C

No affiliation info available

MeSH

AlopeciaEnzyme InhibitorsFinasterideFollow-Up StudiesHumansMaleRandomized Controlled Trials as Topic

Pub Type(s)

English Abstract

Journal Article

Language

ger

PubMed ID

10897972

Citation

Wolff, H, and C Kunte. "[Therapy of Androgenetic Alopecia With Finasteride. what Must Be Considered in Consultation and Drug Prescribing]." MMW Fortschritte Der Medizin, vol. 141, no. 37, 1999, pp. 38-40.

Wolff H, Kunte C. [Therapy of androgenetic alopecia with finasteride. What must be considered in consultation and drug prescribing]. MMW Fortschr Med. 1999;141(37):38-40.

Wolff, H., & Kunte, C. (1999). [Therapy of androgenetic alopecia with finasteride. What must be considered in consultation and drug prescribing]. MMW Fortschritte Der Medizin, 141(37), 38-40.

Wolff H, Kunte C. [Therapy of Androgenetic Alopecia With Finasteride. what Must Be Considered in Consultation and Drug Prescribing]. MMW Fortschr Med. 1999 Sep 16;141(37):38-40. PubMed PMID: 10897972.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Therapy of androgenetic alopecia with finasteride. What must be considered in consultation and drug prescribing]. AU - Wolff,H, AU - Kunte,C, PY - 2000/7/18/pubmed PY - 2000/8/19/medline PY - 2000/7/18/entrez SP - 38 EP - 40 JF - MMW Fortschritte der Medizin JO - MMW Fortschr Med VL - 141 IS - 37 N2 - Androgenetic alopecia in men is genetically determined, but occurs only when the testosterone metabolite dihydrotestosterone (DHT) is present in normal levels. The drug, finasteride, inhibits the enzyme 5-alpha-reductase II, which is responsible for converting testosterone to DHT. One 1 mg tablet (Propecia) of finasteride daily lowers serum DHT levels by about 70%, and increases serum testosterone by 10%. The efficacy of finasteride 1 mg has been demonstrated in a randomized, double-blind, placebo-controlled clinical trial involving more than 1,500 men in whom a significant increase in hair density over a specified area of the scalp, and a significant improvement in appearance was noted. Following one year to treatment 48%, and following 2 years 66%, of the finasteride patients (placebo group 7% after both treatment periods) presented with visibly thicker hair growth. Side effects such as decreased libido, ejaculation disorders and erectile dysfunction were seen in fewer than 2% of the men in both the finasteride and placebo groups. SN - 1438-3276 UR - https://www.unboundmedicine.com/medline/citation/10897972/[Therapy_of_androgenetic_alopecia_with_finasteride__What_must_be_considered_in_consultation_and_drug_prescribing]_ L2 - http://www.diseaseinfosearch.org/result/440 DB - PRIME DP - Unbound Medicine ER -

Tags

[Therapy of androgenetic alopecia with finasteride. What must be considered in consultation and drug prescribing].MMW Fortschr Med. 1999 Sep 16; 141(37):38-40.MF