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Dyslipidemia in peritoneal dialysis--relation to dialytic variables.
Perit Dial Int 2000 May-Jun; 20(3):306-14PD

Abstract

OBJECTIVE

To investigate whether the specific lipoprotein (LP) abnormalities of peritoneal dialysis (PD) are associated with functional variables of this mode of dialysis.

DESIGN

A survey of the LP profile in relation to peritoneal dialysis capacity (PDC) variables. The LP profile was compared to that of a group of age- and sex-matched controls.

SETTING

The Peritoneal Dialysis Unit at Sahlgrenska University Hospital in Gothenburg, Sweden.

PATIENTS

Twenty-two nondiabetic PD patients (5 women, 17 men) who had been on PD for at least 6 months.

MAIN OUTCOME MEASURES

The LP profile included plasma lipids, apolipoproteins (Apo), and individual ApoA- and ApoB-containing LP. The PDC measurement determined peritoneal glucose uptake, protein losses, effective peritoneal surface area, and total weekly creatinine clearance.

RESULTS

The patients had been on PD for 6 to 48 months (mean 15.3 months) and had a total weekly creatinine clearance of 69.7+/-13.3 L/1.73 m2 body surface area, an average peritoneal glucose uptake corresponding to 446+/-162 kcal/24 hour, and a protein loss of 8.1+/-2.5 g/24 hr. The patients had significantly higher total cholesterol (7.1 mmol/L),VLDL-cholesterol (1.0 mmol/L), LDL-cholesterol (4.7 mmol/L), and triglyceride levels (2.5 mmol/L); whereas the HDL-cholesterol level (1.2 mmol/L) was significantly lower than in controls. The PD patients had increased levels of ApoB-containing LPs, both of the cholesterol-rich LP-B and of the triglyceride-rich LP-B complex, reflected in higher plasma concentrations of ApoB, ApoC-III, and ApoE. Furthermore, they had significantly lower levels of LP-A-I:A-II, as well as of ApoA-I and ApoA-II. The LP-A-I:A-II and ApoA-II levels correlated inversely with the duration of PD treatment (r = 0.54, p < 0.01 and r = 0.52, p < 0.05, respectively). The ApoA-II level was inversely correlated with the peritoneal surface area (r = 0.53, p < 0.05). There were no other correlations between LP variables and PDC variables, nor did any of the LP variables correlate with peritoneal glucose uptake or protein losses.

CONCLUSION

The proatherogenic lipoprotein profile of patients on PD is characterized by increased concentrations of cholesterol-rich and triglyceride-rich ApoB-containing LPs. While the duration of treatment appears to have some influence on the development of this type of dyslipidemia, the pathophysiological links to the dialysis mode must be further explored.

Authors+Show Affiliations

Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10898048

Citation

Johansson, A C., et al. "Dyslipidemia in Peritoneal Dialysis--relation to Dialytic Variables." Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, vol. 20, no. 3, 2000, pp. 306-14.
Johansson AC, Samuelsson O, Attman PO, et al. Dyslipidemia in peritoneal dialysis--relation to dialytic variables. Perit Dial Int. 2000;20(3):306-14.
Johansson, A. C., Samuelsson, O., Attman, P. O., Haraldsson, B., Moberly, J., Knight-Gibson, C., & Alaupovic, P. (2000). Dyslipidemia in peritoneal dialysis--relation to dialytic variables. Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, 20(3), pp. 306-14.
Johansson AC, et al. Dyslipidemia in Peritoneal Dialysis--relation to Dialytic Variables. Perit Dial Int. 2000;20(3):306-14. PubMed PMID: 10898048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyslipidemia in peritoneal dialysis--relation to dialytic variables. AU - Johansson,A C, AU - Samuelsson,O, AU - Attman,P O, AU - Haraldsson,B, AU - Moberly,J, AU - Knight-Gibson,C, AU - Alaupovic,P, PY - 2000/7/18/pubmed PY - 2001/2/28/medline PY - 2000/7/18/entrez SP - 306 EP - 14 JF - Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis JO - Perit Dial Int VL - 20 IS - 3 N2 - OBJECTIVE: To investigate whether the specific lipoprotein (LP) abnormalities of peritoneal dialysis (PD) are associated with functional variables of this mode of dialysis. DESIGN: A survey of the LP profile in relation to peritoneal dialysis capacity (PDC) variables. The LP profile was compared to that of a group of age- and sex-matched controls. SETTING: The Peritoneal Dialysis Unit at Sahlgrenska University Hospital in Gothenburg, Sweden. PATIENTS: Twenty-two nondiabetic PD patients (5 women, 17 men) who had been on PD for at least 6 months. MAIN OUTCOME MEASURES: The LP profile included plasma lipids, apolipoproteins (Apo), and individual ApoA- and ApoB-containing LP. The PDC measurement determined peritoneal glucose uptake, protein losses, effective peritoneal surface area, and total weekly creatinine clearance. RESULTS: The patients had been on PD for 6 to 48 months (mean 15.3 months) and had a total weekly creatinine clearance of 69.7+/-13.3 L/1.73 m2 body surface area, an average peritoneal glucose uptake corresponding to 446+/-162 kcal/24 hour, and a protein loss of 8.1+/-2.5 g/24 hr. The patients had significantly higher total cholesterol (7.1 mmol/L),VLDL-cholesterol (1.0 mmol/L), LDL-cholesterol (4.7 mmol/L), and triglyceride levels (2.5 mmol/L); whereas the HDL-cholesterol level (1.2 mmol/L) was significantly lower than in controls. The PD patients had increased levels of ApoB-containing LPs, both of the cholesterol-rich LP-B and of the triglyceride-rich LP-B complex, reflected in higher plasma concentrations of ApoB, ApoC-III, and ApoE. Furthermore, they had significantly lower levels of LP-A-I:A-II, as well as of ApoA-I and ApoA-II. The LP-A-I:A-II and ApoA-II levels correlated inversely with the duration of PD treatment (r = 0.54, p < 0.01 and r = 0.52, p < 0.05, respectively). The ApoA-II level was inversely correlated with the peritoneal surface area (r = 0.53, p < 0.05). There were no other correlations between LP variables and PDC variables, nor did any of the LP variables correlate with peritoneal glucose uptake or protein losses. CONCLUSION: The proatherogenic lipoprotein profile of patients on PD is characterized by increased concentrations of cholesterol-rich and triglyceride-rich ApoB-containing LPs. While the duration of treatment appears to have some influence on the development of this type of dyslipidemia, the pathophysiological links to the dialysis mode must be further explored. SN - 0896-8608 UR - https://www.unboundmedicine.com/medline/citation/10898048/Dyslipidemia_in_peritoneal_dialysis__relation_to_dialytic_variables_ L2 - http://www.pdiconnect.com/cgi/pmidlookup?view=long&amp;pmid=10898048 DB - PRIME DP - Unbound Medicine ER -