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Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction.
J Am Coll Cardiol. 2000 Jul; 36(1):276-81.JACC

Abstract

OBJECTIVES

We sought to compare the effects of two different beta-blockers, carvedilol and metoprolol, to an angiotensin-converting enzyme (ACE) inhibitor (captopril) on myocardial collagen deposition during healing and ventricular remodeling after myocardial infarction (MI).

BACKGROUND

Beta-adrenergic blockade has been shown to be beneficial post-MI and in chronic heart failure. Carvedilol is a new-generation vasodilating beta-blocker with additional alpha1-adrenoceptor antagonism and an antiproliferative action, but it is not known if it is more beneficial than standard selective beta-blockers.

METHODS

Using a rat model of MI, induced by left coronary ligation, we studied the effects of 11 weeks of therapy with oral carvedilol, metoprolol or captopril on hemodynamics, tissue weights, collagen volume fraction and hydroxyproline content.

RESULTS

Both beta-blockers caused similar decreases in heart rate and LVEDP compared with untreated post-MI rats. At equivalent beta-adrenoceptor blocking doses, however, carvedilol, but not metoprolol, attenuated the increase in collagen content in noninfarcted regions and prevented the increase in right ventricular weight/body weight (all p < 0.05), and its effect was similar to captopril. Metoprolol treatment tended to increase right ventricular weight and heart weight (p < 0.05). There were no differences in infarct size between the groups.

CONCLUSIONS

Long-term treatment with both beta-blockers, as well as an ACE inhibitor, benefited the healing process in rats post-MI. At equivalent myocardial beta-adrenoceptor blocking doses, however, carvedilol significantly reduced myocardial collagen in the noninfarcted myocardium and cardiac hypertrophy in the right ventricle, whereas metoprolol had no effect on myocardial collagen deposition.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10898446

Citation

Wei, S, et al. "Effect of Carvedilol in Comparison With Metoprolol On Myocardial Collagen Postinfarction." Journal of the American College of Cardiology, vol. 36, no. 1, 2000, pp. 276-81.
Wei S, Chow LT, Sanderson JE. Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction. J Am Coll Cardiol. 2000;36(1):276-81.
Wei, S., Chow, L. T., & Sanderson, J. E. (2000). Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction. Journal of the American College of Cardiology, 36(1), 276-81.
Wei S, Chow LT, Sanderson JE. Effect of Carvedilol in Comparison With Metoprolol On Myocardial Collagen Postinfarction. J Am Coll Cardiol. 2000;36(1):276-81. PubMed PMID: 10898446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction. AU - Wei,S, AU - Chow,L T, AU - Sanderson,J E, PY - 2000/7/18/pubmed PY - 2000/8/6/medline PY - 2000/7/18/entrez SP - 276 EP - 81 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 36 IS - 1 N2 - OBJECTIVES: We sought to compare the effects of two different beta-blockers, carvedilol and metoprolol, to an angiotensin-converting enzyme (ACE) inhibitor (captopril) on myocardial collagen deposition during healing and ventricular remodeling after myocardial infarction (MI). BACKGROUND: Beta-adrenergic blockade has been shown to be beneficial post-MI and in chronic heart failure. Carvedilol is a new-generation vasodilating beta-blocker with additional alpha1-adrenoceptor antagonism and an antiproliferative action, but it is not known if it is more beneficial than standard selective beta-blockers. METHODS: Using a rat model of MI, induced by left coronary ligation, we studied the effects of 11 weeks of therapy with oral carvedilol, metoprolol or captopril on hemodynamics, tissue weights, collagen volume fraction and hydroxyproline content. RESULTS: Both beta-blockers caused similar decreases in heart rate and LVEDP compared with untreated post-MI rats. At equivalent beta-adrenoceptor blocking doses, however, carvedilol, but not metoprolol, attenuated the increase in collagen content in noninfarcted regions and prevented the increase in right ventricular weight/body weight (all p < 0.05), and its effect was similar to captopril. Metoprolol treatment tended to increase right ventricular weight and heart weight (p < 0.05). There were no differences in infarct size between the groups. CONCLUSIONS: Long-term treatment with both beta-blockers, as well as an ACE inhibitor, benefited the healing process in rats post-MI. At equivalent myocardial beta-adrenoceptor blocking doses, however, carvedilol significantly reduced myocardial collagen in the noninfarcted myocardium and cardiac hypertrophy in the right ventricle, whereas metoprolol had no effect on myocardial collagen deposition. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/10898446/Effect_of_carvedilol_in_comparison_with_metoprolol_on_myocardial_collagen_postinfarction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(00)00671-9 DB - PRIME DP - Unbound Medicine ER -